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Ndel1 Gene Detail
Summary
  • Symbol
    Ndel1
  • Name
    nudE neurodevelopment protein 1 like 1
  • Synonyms
    2600006O07Rik, mNudel
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932915
    NCBI Gene: 83431
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68712260-68743961 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932915
 protein coding gene Chr11:68712260-68762684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018505
 protein coding gene Chr11:69194757-69253067 (-)
A/J MGP_AJ_G0018474
 protein coding gene Chr11:66606664-66659038 (-)
AKR/J MGP_AKRJ_G0018443
 protein coding gene Chr11:68591903-68645497 (-)
BALB/cJ MGP_BALBcJ_G0018445
 protein coding gene Chr11:66892434-66952984 (-)
C3H/HeJ MGP_C3HHeJ_G0018258
 protein coding gene Chr11:68612116-68667822 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018897
 protein coding gene Chr11:71295026-71361239 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016541
 protein coding gene Chr11:63549856-63596114 (-)
CAST/EiJ MGP_CASTEiJ_G0017814
 protein coding gene Chr11:68842822-68903349 (-)
CBA/J MGP_CBAJ_G0018232
 protein coding gene Chr11:74459134-74521152 (-)
DBA/2J MGP_DBA2J_G0018341
 protein coding gene Chr11:66203474-66253645 (-)
FVB/NJ MGP_FVBNJ_G0018331
 protein coding gene Chr11:65825737-65877109 (-)
LP/J MGP_LPJ_G0018412
 protein coding gene Chr11:69771723-69831740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018354
 protein coding gene Chr11:75149740-75210270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018938
 protein coding gene Chr11:68836150-68893082 (-)
PWK/PhJ MGP_PWKPhJ_G0017589
 protein coding gene Chr11:66827781-66881483 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017377
 protein coding gene Chr11:68669224-68722621 (-)
WSB/EiJ MGP_WSBEiJ_G0017867
 protein coding gene Chr11:68471978-68530167 (-)



Homology
more
  • Human Ortholog
    NDEL1, nudE neurodevelopment protein 1 like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDEL1, nudE neurodevelopment protein 1 like 1
  • Synonyms
    EOPA, MITAP1, NDE1L1, NDE2, NUDEL
  • Links
    NCBI Gene ID: 81565
    neXtProt AC: NX_Q9GZM8
    UniProt: Q9GZM8

  • Chr Location
    17p13.1; chr17:8413131-8490411 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes peri-implantation lethality. Blastocysts fail to grow in culture and exhibit inner cell mass degeneration. Compound heterozygous mice carrying one null and one hypomorphic allele show mild neuronal migration defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    149
  • cDNA Data
    13
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83431 NCBI Gene Model | MGI Sequence Detail 31702 C57BL/6J ±  kb
    transcript NM_001363304 RefSeq | MGI Sequence Detail 2417 C57BL/6  
    polypeptide Q9ERR1 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919693
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 20
      Gene Ontology 25
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory