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Grin3a Gene Detail
Summary
  • Symbol
    Grin3a
  • Name
    glutamate receptor ionotropic, NMDA3A
  • Synonyms
    A830097C19Rik, NMDAR-L, NR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933206
    NCBI Gene: 242443
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49661611-49845744 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933206
 protein coding gene Chr4:49661611-49846023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028287
 protein coding gene Chr4:48145645-48342576 (-)
A/J MGP_AJ_G0028247
 protein coding gene Chr4:46370407-46549078 (-)
AKR/J MGP_AKRJ_G0028196
 protein coding gene Chr4:47583894-47771931 (-)
BALB/cJ MGP_BALBcJ_G0028266
 protein coding gene Chr4:46476294-46666434 (-)
C3H/HeJ MGP_C3HHeJ_G0027987
 protein coding gene Chr4:48153260-48356488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028707
 protein coding gene Chr4:49879270-50076418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026016
 protein coding gene Chr4:43572407-43748466 (-)
CAST/EiJ MGP_CASTEiJ_G0027426
 protein coding gene Chr4:47712096-47903467 (-)
CBA/J MGP_CBAJ_G0027953
 protein coding gene Chr4:51581810-51785119 (-)
DBA/2J MGP_DBA2J_G0028103
 protein coding gene Chr4:46252858-46431905 (-)
FVB/NJ MGP_FVBNJ_G0028070
 protein coding gene Chr4:45515733-45695438 (-)
LP/J MGP_LPJ_G0028202
 protein coding gene Chr4:48223392-48416573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028094
 protein coding gene Chr4:54503292-54700150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028742
 protein coding gene Chr4:47791625-47972777 (-)
PWK/PhJ MGP_PWKPhJ_G0027151
 protein coding gene Chr4:46327439-46510150 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026979
 protein coding gene Chr4:47160885-47364040 (-)
WSB/EiJ MGP_WSBEiJ_G0027504
 protein coding gene Chr4:47686704-47882521 (-)



Homology
more
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Synonyms
    GluN3A, NMDAR3A, NMDAR-L, NR3A
  • Links
    NCBI Gene ID: 116443
    neXtProt AC: NX_Q8TCU5
    UniProt: Q8TCU5

  • Chr Location
    9q31.1; chr9:101569352-101738647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    41
  • cDNA Data
    22
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039579 Ensembl Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
    transcript ENSMUST00000093859 Ensembl | MGI Sequence Detail 7491 Not Applicable  
    polypeptide ENSMUSP00000091381 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008250 glutamate receptor ionotropic, NMDA 3A
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      A2AIR5 12 sites, 7 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3036253
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 33
    • Earliest
      J:6648 Billings-Gagliardi S, et al., Hypomyelinated mutant mice IV: peripheral myelin in jp msd. Brain Res. 1981 Nov 30;225(2):309-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory