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Ifitm2 Gene Detail
Summary
  • Symbol
    Ifitm2
  • Name
    interferon induced transmembrane protein 2
  • Synonyms
    fragilis3, Ifitm3l, mil-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933382
    NCBI Gene: 80876
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140534750-140535900 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.18 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933382
 protein coding gene Chr7:140534750-140539602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033203
 protein coding gene Chr7:146092299-146093988 (-)
A/J MGP_AJ_G0033185
 protein coding gene Chr7:141938735-141939857 (-)
AKR/J MGP_AKRJ_G0033117
 protein coding gene Chr7:145829340-145830474 (-)
BALB/cJ MGP_BALBcJ_G0033186
 protein coding gene Chr7:141666463-141667940 (-)
C3H/HeJ MGP_C3HHeJ_G0032900
 protein coding gene Chr7:145586438-145588077 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033697
 protein coding gene Chr7:151437715-151438837 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030670
 protein coding gene Chr7:143149727-143150834 (-)
CAST/EiJ MGP_CASTEiJ_G0032230
 protein coding gene Chr7:137886781-137889300 (-)
CBA/J MGP_CBAJ_G0032872
 protein coding gene Chr7:156567008-156568448 (-)
DBA/2J MGP_DBA2J_G0033025
 protein coding gene Chr7:139876782-139878385 (-)
FVB/NJ MGP_FVBNJ_G0032977
 protein coding gene Chr7:139789454-139791488 (-)
LP/J MGP_LPJ_G0033119
 protein coding gene Chr7:147596751-147599422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033010
 protein coding gene Chr7:157228854-157229976 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033717
 protein coding gene Chr7:144813493-144814615 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0031781
 protein coding gene Chr7:131629993-131633393 (-)
WSB/EiJ MGP_WSBEiJ_G0032341
 protein coding gene Chr7:145735237-145736347 (-)



Homology
more
  • Human Ortholog
    IFITM2, interferon induced transmembrane protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFITM2, interferon induced transmembrane protein 2
  • Synonyms
    1-8D, DSPA2c
  • Links
    NCBI Gene ID: 10581
    neXtProt AC: NX_Q01629
    UniProt: Q01629

  • Chr Location
    11p15.5; chr11:303655-309397 (+)  GRCh38
  • Human Ortholog
    IFITM3, interferon induced transmembrane protein 3
  • Synonyms
    1-8U, DSPA2b, IP15
  • Links
    NCBI Gene ID: 10410
    neXtProt AC: NX_Q01628
    UniProt: Q01628

  • Chr Location
    11p15.5; chr11:319676-329475 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IFITM3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    21
  • cDNA Data
    178
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060591 Ensembl Gene Model | MGI Sequence Detail 1151 C57BL/6J ±  kb
transcript ENSMUST00000081649 Ensembl | MGI Sequence Detail 655 Not Applicable  
polypeptide ENSMUSP00000071470 Ensembl | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007593 CD225/Dispanin family
    IPR051517 Interferon-induced transmembrane antiviral protein
Molecular
Reagents
less
  • All nucleic 181
    cDNA 178
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 55
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory