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Hamp Gene Detail
Summary
  • Symbol
    Hamp
  • Name
    hepcidin antimicrobial peptide
  • Synonyms
    Hepc, HEPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933533
    NCBI Gene: 84506
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30641793-30643454 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.27 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933533
 protein coding gene Chr7:30641793-30643457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032053
 protein coding gene Chr7:29994786-29996031 (-)
A/J MGP_AJ_G0032029
 protein coding gene Chr7:29166302-29167966 (-)
AKR/J MGP_AKRJ_G0031962
 protein coding gene Chr7:29911823-29917517 (-)
BALB/cJ MGP_BALBcJ_G0032037
 protein coding gene Chr7:29356459-29358123 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032503
 protein coding gene Chr7:30988844-30990258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029552
 protein coding gene Chr7:30143667-30145338 (-)
CAST/EiJ MGP_CASTEiJ_G0031089
 protein coding gene Chr7:23629393-23633016 (+)
CBA/J MGP_CBAJ_G0031720
 protein coding gene Chr7:32422042-32423349 (-)
DBA/2J MGP_DBA2J_G0031873
 protein coding gene Chr7:28900070-28901837 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031954
 protein coding gene Chr7:30302623-30304720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031866
 protein coding gene Chr7:31681509-31683173 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030647
 protein coding gene Chr7:20405096-20408901 (-)
WSB/EiJ MGP_WSBEiJ_G0031199
 protein coding gene Chr7:29816275-29817949 (-)



Homology
more
  • Human Ortholog
    HAMP, hepcidin antimicrobial peptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAMP, hepcidin antimicrobial peptide
  • Synonyms
    HEPC, HFE2B, LEAP1, PLTR
  • Links
    NCBI Gene ID: 57817
    neXtProt AC: NX_P81172
    UniProt: P81172

  • Chr Location
    19q13.12; chr19:35280716-35285143 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hamp mouse models; 3 with human HAMP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutations in this gene result in abnormal iron homeostasis, with massive iron accumulation observed in the liver, pancreas, and heart of mice. Serum iron content is also elevated, while splenic iron content is significantly decreased compared to wild type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    6
  • cDNA Data
    18
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 84506 NCBI Gene Model | MGI Sequence Detail 1662 C57BL/6J ±  kb
    transcript NM_032541 RefSeq | MGI Sequence Detail 422 ZRU/MplStud  
    polypeptide Q9EQ21 UniProt | EBI | MGI Sequence Detail 83 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR010500 Hepcidin
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 24
      Phenotypes 61
    • Earliest
      J:8030 Venta PJ, et al., Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene. J Biol Chem. 1985 Oct 5;260(22):12130-5
    • Latest
      J:344220 Bai X, et al., Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. J Neuroinflammation. 2024 Jan 9;21(1):15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory