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Tas1r2 Gene Detail
Summary
  • Symbol
    Tas1r2
  • Name
    taste receptor, type 1, member 2
  • Synonyms
    Gpr71, T1r2, TR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933546
    NCBI Gene: 83770
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:139380849-139397591 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    662 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933546
 protein coding gene Chr4:139380849-139397591 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029022
 protein coding gene Chr4:142502719-142522573 (+)
A/J MGP_AJ_G0028981
 protein coding gene Chr4:136376817-136393490 (+)
AKR/J MGP_AKRJ_G0028933
 protein coding gene Chr4:140286492-140302800 (+)
BALB/cJ MGP_BALBcJ_G0029005
 protein coding gene Chr4:137054019-137071270 (+)
C3H/HeJ MGP_C3HHeJ_G0028719
 protein coding gene Chr4:140674644-140692048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029446
 protein coding gene Chr4:147555107-147571647 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026717
 protein coding gene Chr4:129327022-129344850 (+)
CAST/EiJ MGP_CASTEiJ_G0028151
 protein coding gene Chr4:138866888-138887334 (+)
CBA/J MGP_CBAJ_G0028683
 protein coding gene Chr4:151795773-151814010 (+)
DBA/2J MGP_DBA2J_G0028833
 protein coding gene Chr4:136776332-136792625 (+)
FVB/NJ MGP_FVBNJ_G0028800
 protein coding gene Chr4:135811939-135828464 (+)
LP/J MGP_LPJ_G0028932
 protein coding gene Chr4:142582328-142598856 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028826
 protein coding gene Chr4:155689300-155707088 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029484
 protein coding gene Chr4:140809476-140827077 (+)
PWK/PhJ MGP_PWKPhJ_G0027872
 protein coding gene Chr4:133624497-133640918 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027697
 protein coding gene Chr4:136600792-136617237 (+)
WSB/EiJ MGP_WSBEiJ_G0028229
 protein coding gene Chr4:141072957-141090947 (+)



Homology
more
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
  • Synonyms
    GPR71, T1R2, TR2
  • Links
    NCBI Gene ID: 80834
    neXtProt AC: NX_Q8TE23
    UniProt: Q8TE23

  • Chr Location
    1p36.13; chr1:18839599-18859660 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    1
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83770 NCBI Gene Model | MGI Sequence Detail 16743 C57BL/6J ±  kb
    transcript NM_031873 RefSeq | MGI Sequence Detail 3060 ZRU/MplStud  
    polypeptide Q925I4 UniProt | EBI | MGI Sequence Detail 843 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 3
      cDNA 1
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1340027
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
    • Latest
      J:352599 Serrano J, et al., The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity. Nat Commun. 2024 Jun 8;15(1):4915
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory