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Nedd4l Gene Detail
Summary
  • Symbol
    Nedd4l
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 4-like
  • Synonyms
    1300012C07Rik, Nedd4-2, Nedd4b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933754
    NCBI Gene: 83814
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65020776-65350899 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.57 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933754
 protein coding gene Chr18:65017551-65350899 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024506
 protein coding gene Chr18:64989987-65337561 (+)
A/J MGP_AJ_G0024473
 protein coding gene Chr18:62177561-62513855 (+)
AKR/J MGP_AKRJ_G0024443
 protein coding gene Chr18:63917246-64267937 (+)
BALB/cJ MGP_BALBcJ_G0024472
 protein coding gene Chr18:62318475-62651077 (+)
C3H/HeJ MGP_C3HHeJ_G0024240
 protein coding gene Chr18:64133697-64475221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024919
 protein coding gene Chr18:66727029-67098995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022350
 protein coding gene Chr18:61625291-61953575 (+)
CAST/EiJ MGP_CASTEiJ_G0023713
 protein coding gene Chr18:64081081-64428358 (+)
CBA/J MGP_CBAJ_G0024210
 protein coding gene Chr18:68898387-69273518 (+)
DBA/2J MGP_DBA2J_G0024340
 protein coding gene Chr18:61835144-62165476 (+)
FVB/NJ MGP_FVBNJ_G0024306
 protein coding gene Chr18:61217254-61557732 (+)
LP/J MGP_LPJ_G0024424
 protein coding gene Chr18:64842140-65198773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024335
 protein coding gene Chr18:70363609-70728868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024966
 protein coding gene Chr18:64146645-64494025 (+)
PWK/PhJ MGP_PWKPhJ_G0023456
 protein coding gene Chr18:62080081-62420410 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023261
 protein coding gene Chr18:64288527-64631786 (+)
WSB/EiJ MGP_WSBEiJ_G0023777
 protein coding gene Chr18:63992320-64343471 (+)



Homology
more
  • Human Ortholog
    NEDD4L, NEDD4 like E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEDD4L, NEDD4 like E3 ubiquitin protein ligase
  • Synonyms
    hNEDD4-2, NEDD4-2, NEDD4.2, PVNH7, RSP5
  • Links
    NCBI Gene ID: 23327
    neXtProt AC: NX_Q96PU5
    UniProt: Q96PU5

  • Chr Location
    18q21.31; chr18:58044226-58401540 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEDD4L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    64
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024589 Ensembl Gene Model | MGI Sequence Detail 330124 C57BL/6J ±  kb
    transcript ENSMUST00000236898 Ensembl | MGI Sequence Detail 3034 Not Applicable  
    polypeptide ENSMUSP00000158272 Ensembl | MGI Sequence Detail 1004 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1921413
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 12
      Gene Ontology 20
      Phenotypes 52
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:351624 Blackburn DM, et al., The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation. iScience. 2024 Jul 19;27(7):110241
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory