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Jam2 Gene Detail
Summary
  • Symbol
    Jam2
  • Name
    junction adhesion molecule 2
  • Synonyms
    2410030G21Rik, 2410167M24Rik, JAM-2, Jcam2, VE-JAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933820
    NCBI Gene: 67374
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84571011-84622816 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 46.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1735 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933820
 protein coding gene Chr16:84571011-84623268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022968
 protein coding gene Chr16:85347727-85408105 (+)
A/J MGP_AJ_G0022936
 protein coding gene Chr16:81460379-81515716 (+)
AKR/J MGP_AKRJ_G0022906
 protein coding gene Chr16:83862294-83915770 (+)
BALB/cJ MGP_BALBcJ_G0022938
 protein coding gene Chr16:81918700-81974226 (+)
C3H/HeJ MGP_C3HHeJ_G0022700
 protein coding gene Chr16:84434672-84490880 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023385
 protein coding gene Chr16:88125093-88181932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020889
 protein coding gene Chr16:79406002-79461924 (+)
CAST/EiJ MGP_CASTEiJ_G0022222
 protein coding gene Chr16:84878016-84936655 (+)
CBA/J MGP_CBAJ_G0022669
 protein coding gene Chr16:91885045-91940473 (+)
DBA/2J MGP_DBA2J_G0022803
 protein coding gene Chr16:81343110-81395008 (+)
FVB/NJ MGP_FVBNJ_G0022778
 protein coding gene Chr16:80541668-80594137 (+)
LP/J MGP_LPJ_G0022872
 protein coding gene Chr16:85035798-85093521 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022797
 protein coding gene Chr16:96327420-96400165 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023403
 protein coding gene Chr16:84340021-84395045 (+)
PWK/PhJ MGP_PWKPhJ_G0021964
 protein coding gene Chr16:81501580-81556577 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021794
 protein coding gene Chr16:83831957-83887730 (+)
WSB/EiJ MGP_WSBEiJ_G0022270
 protein coding gene Chr16:84589219-84643346 (+)



Homology
more
  • Human Ortholog
    JAM2, junctional adhesion molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JAM2, junctional adhesion molecule 2
  • Synonyms
    C21orf43, CD322, IBGC8, JAM-B, JAMB, PRO245, VE-JAM, VEJAM
  • Links
    NCBI Gene ID: 58494
    neXtProt AC: NX_P57087
    UniProt: P57087

  • Chr Location
    21q21.3; chr21:25639258-25717562 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human JAM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable spermatogenesis abnormalities or defects in embryonic, neural and hematopoietic stem cell properties.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    999
  • Tissues
    168
  • cDNA Data
    46
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053062 Ensembl Gene Model | MGI Sequence Detail 51806 C57BL/6J ±  kb
    transcript ENSMUST00000231910 Ensembl | MGI Sequence Detail 1214 Not Applicable  
    polypeptide ENSMUSP00000156235 Ensembl | MGI Sequence Detail 322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 47
      Primer pair 5
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1914168, MGI:1924075, MGI:2146545
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 10
      Phenotypes 36
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory