Notch1<tm1Agt> Targeted Allele Detail MGI Mouse (MGI:1933835)

Notch1^tm1Agt
Targeted Allele Detail

Summary

Symbol:	Notch1^tm1Agt
Name:	notch 1; targeted mutation 1, Michael Aguet
MGI ID:	MGI:1933835
Synonyms:	floxNotch1, N1^flox, Notch1^F, Notch1^flox, Notch1^lox
Gene:	Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
Alliance:	Notch1^tm1Agt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:55400
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Insertion of loxP sites flanking the first coding exon of the gene. This mutation had no effect on the normal function of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:55400)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	33 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Notch1^tm1Agt

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Notch1 Mutation:	117 strains or lines available

References

Original:	J:55400 Radtke F, et al., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999 May;10(5):547-58
All:	122 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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