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Sucnr1 Gene Detail
Summary
  • Symbol
    Sucnr1
  • Name
    succinate receptor 1
  • Synonyms
    Gpr91
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934135
    NCBI Gene: 84112
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59989290-59994987 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.17 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934135
 protein coding gene Chr3:59989290-59994987 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027253
 protein coding gene Chr3:58965213-58970862 (+)
A/J MGP_AJ_G0027213
 protein coding gene Chr3:57250955-57256622 (+)
AKR/J MGP_AKRJ_G0027183
 protein coding gene Chr3:58367487-58373146 (+)
BALB/cJ MGP_BALBcJ_G0027226
 protein coding gene Chr3:56988839-56994482 (+)
C3H/HeJ MGP_C3HHeJ_G0026969
 protein coding gene Chr3:58562134-58567783 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027672
 protein coding gene Chr3:61186531-61192163 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025026
 protein coding gene Chr3:53385260-53393028 (+)
CAST/EiJ MGP_CASTEiJ_G0026421
 protein coding gene Chr3:58746862-58753507 (+)
CBA/J MGP_CBAJ_G0026945
 protein coding gene Chr3:63210705-63216354 (+)
DBA/2J MGP_DBA2J_G0027079
 protein coding gene Chr3:56679722-56685612 (+)
FVB/NJ MGP_FVBNJ_G0027047
 protein coding gene Chr3:55581961-55587998 (+)
LP/J MGP_LPJ_G0027190
 protein coding gene Chr3:59793561-59799208 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027064
 protein coding gene Chr3:67369125-67375586 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027730
 protein coding gene Chr3:58279848-58286166 (+)
PWK/PhJ MGP_PWKPhJ_G0026153
 protein coding gene Chr3:56316564-56324471 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025966
 protein coding gene Chr3:57886122-57895904 (+)
WSB/EiJ MGP_WSBEiJ_G0026495
 protein coding gene Chr3:58400617-58406254 (+)



Homology
more
  • Human Ortholog
    SUCNR1, succinate receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCNR1, succinate receptor 1
  • Synonyms
    GPR91
  • Links
    NCBI Gene ID: 56670
    neXtProt AC: NX_Q9BXA5
    UniProt: Q9BXA5

  • Chr Location
    3q25.1; chr3:151873643-151884619 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased renin plasma and kidney levels upon high-glucose stimulation in a diabetic or non-diabetic model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 84112 NCBI Gene Model | MGI Sequence Detail 5698 C57BL/6J ±  kb
    transcript NM_032400 RefSeq | MGI Sequence Detail 1571 C57BL/6  
    polypeptide Q99MT6 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:68335 Wittenberger T, et al., An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol. 2001 Mar 30;307(3):799-813
    • Latest
      J:349170 Billipp TE, et al., Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance. Immunity. 2024 May 6;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory