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Ihhtm1Amc
Targeted Allele Detail
Summary
Symbol: Ihhtm1Amc
Name: Indian hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1934258
Synonyms: Ihh-, Ihhn
Gene: Ihh  Location: Chr1:74984474-74990831 bp, - strand  Genetic Position: Chr1, 38.55 cM
Alliance: Ihhtm1Amc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57297
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced the entire first exon, which encodes much of the signaling peptide, and approximately 1kb of flanking sequence. (J:57297)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 230 assay results
In Structures Affected by this Mutation: 32 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ihh Mutation:  22 strains or lines available
References
Original:  J:57297 St-Jacques B, et al., Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]. Genes Dev. 1999 Aug 15;13(16):2072-86
All:  49 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory