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Dhhtm1Amc
Targeted Allele Detail
Summary
Symbol: Dhhtm1Amc
Name: desert hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1934259
Synonyms: Dhh-
Gene: Dhh  Location: Chr15:98789033-98796421 bp, - strand  Genetic Position: Chr15, 55.05 cM
Alliance: Dhhtm1Amc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57914
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1, 2 and part of 3 were replaced with a neomycin cassette. The deleted segments encode a conserved polypeptide required for protein function. Thus, no functional protein is predicted to be produced from this allele. (J:57914)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dhh Mutation:  23 strains or lines available
References
Original:  J:57914 Bitgood MJ, et al., Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996 Mar 1;6(3):298-304
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory