Shh<tm1Amc> Targeted Allele Detail MGI Mouse (MGI:1934261)

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Shh^tm1Amc
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Shh^tm1Amc
Name:	sonic hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:1934261
Synonyms:	Shh-, Shhⁿ
Gene:	Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
Alliance:	Shh^tm1Amc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:50050
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin resistance gene cassette replaced exon 2 and portions of the flanking intronic sequences. (J:50050)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	321 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	59 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Shh Mutation:	48 strains or lines available

References

Original:	J:50050 St-Jacques B, et al., Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998 Sep 24;8(19):1058-68
All:	77 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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