Shh<tm2Amc> Targeted Allele Detail MGI Mouse (MGI:1934268)

Shh^tm2Amc
Targeted Allele Detail

Summary

Symbol:	Shh^tm2Amc
Name:	sonic hedgehog; targeted mutation 2, Andrew P McMahon
MGI ID:	MGI:1934268
Synonyms:	Shh^c, Shh^C-NShh, Shh^Co, Shh^f, Shh^flox, Shh^flx, Shh^lox
Gene:	Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
Alliance:	Shh^tm2Amc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:65294
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: LoxP sites were inserted into intronic sequences flanking exon 2. This mutation has no effect on the normal function of this gene. (J:65294)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	157 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Shh^tm2Amc

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Shh Mutation:	48 strains or lines available

References

Original:	J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
All:	145 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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