Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp63tm1Fmc
Name:	transformation related protein 63; targeted mutation 1, Frank McKeon
MGI ID:	MGI:1934269
Synonyms:	p63-, p63 KO, Tp63-
Gene:	Trp63  Location: Chr16:25502513-25710842 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance:	Trp63tm1Fmc page

Germline Transmission:	Earliest citation of germline transmission: J:54637
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 6, 7, 8, encoding sequences corresonding to the DNA-binding domain, and the intervening introns were replaced by a neomycin gene. (J:54637)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	44 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp63tm1Fmc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:	60 strains or lines available

Original:	J:54637 Yang A, et al., p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22;398(6729):714-8
All:	37 reference(s)