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Cxcr6 Gene Detail
Summary
  • Symbol
    Cxcr6
  • Name
    C-X-C motif chemokine receptor 6
  • Synonyms
    BONZO, STRL33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934582
    NCBI Gene: 80901
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123635542-123640819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 74.57 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934582
 protein coding gene Chr9:123635540-123640825 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035484
 protein coding gene Chr9:126858286-126863543 (+)
A/J MGP_AJ_G0035465
 protein coding gene Chr9:122013292-122018569 (+)
AKR/J MGP_AKRJ_G0035398
 protein coding gene Chr9:125278871-125284148 (+)
BALB/cJ MGP_BALBcJ_G0035461
 protein coding gene Chr9:121942526-121947803 (+)
C3H/HeJ MGP_C3HHeJ_G0035168
 protein coding gene Chr9:125727771-125733048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035984
 protein coding gene Chr9:130366261-130371538 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032866
 protein coding gene Chr9:119114583-119119891 (+)
CAST/EiJ MGP_CASTEiJ_G0034473
 protein coding gene Chr9:125776156-125781414 (+)
CBA/J MGP_CBAJ_G0035136
 protein coding gene Chr9:135130214-135135491 (+)
DBA/2J MGP_DBA2J_G0035295
 protein coding gene Chr9:121453729-121459006 (+)
FVB/NJ MGP_FVBNJ_G0035242
 protein coding gene Chr9:120357782-120363059 (+)
LP/J MGP_LPJ_G0035374
 protein coding gene Chr9:127259256-127264513 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035283
 protein coding gene Chr9:135941647-135946924 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036003
 protein coding gene Chr9:125747788-125753065 (+)
PWK/PhJ MGP_PWKPhJ_G0034177
 protein coding gene Chr9:121913014-121918272 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034014
 protein coding gene Chr9:125849511-125854813 (+)
WSB/EiJ MGP_WSBEiJ_G0034593
 protein coding gene Chr9:125580011-125585288 (+)



Homology
more
  • Human Ortholog
    CXCR6, C-X-C motif chemokine receptor 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCR6, C-X-C motif chemokine receptor 6
  • Synonyms
    BONZO, CD186, CDw186, STRL33, TYMSTR
  • Links
    NCBI Gene ID: 10663
    neXtProt AC: NX_O00574
    UniProt: O00574

  • Chr Location
    3p21.31; chr3:45940915-45948351 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A small percentage of mice that are heterozygous or homozygous for a knock-out allele develop medulloblastomas in the cerebellum after 12 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    44
  • cDNA Data
    38
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80901 NCBI Gene Model | MGI Sequence Detail 5278 C57BL/6J ±  kb
transcript NM_030712 RefSeq | MGI Sequence Detail 1893 ZRU/MplStud  
polypeptide Q9EQ16 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143371
References
more
  • Summaries
    All 106
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 71
  • Earliest
    J:65117 Matloubian M, et al., A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct;1(4):298-304
  • Latest
    J:349353 Liang Z, et al., Intestinal CXCR6(+) ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression. Immunity. 2024 May 29;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory