Lama5<tm1Jhm> Targeted Allele Detail MGI Mouse (MGI:1934917)

Lama5^tm1Jhm
Targeted Allele Detail

Summary

Symbol:	Lama5^tm1Jhm
Name:	laminin, alpha 5; targeted mutation 1, Jeffrey H Miner
MGI ID:	MGI:1934917
Synonyms:	Lama5 -
Gene:	Lama5 Location: Chr2:179818166-179867652 bp, - strand Genetic Position: Chr2, 102.7 cM
Alliance:	Lama5^tm1Jhm page

Syndactyly in Lama5^tm1Jhm/Lama5^tm1Jhm embryos

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:51557
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: An in-frame lacZ gene followed by a neomycin cassette replaced sequences encoding the N-terminal domains VI and V. Immunohistochemical analysis did not detect protein in distal limb basal lamina from homozygous mutant mice. (J:51557)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lama5 Mutation:	153 strains or lines available

References

Original:	J:51557 Miner JH, et al., Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol. 1998 Dec 14;143(6):1713-23
All:	26 reference(s)

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