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Rnf111 Gene Detail
Summary
  • Symbol
    Rnf111
  • Name
    ring finger 111
  • Synonyms
    Arkadia
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934919
    NCBI Gene: 93836
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:70332706-70411007 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934919
 protein coding gene Chr9:70332706-70411122 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035000
 protein coding gene Chr9:70496936-70585898 (-)
A/J MGP_AJ_G0034981
 protein coding gene Chr9:68052242-68134149 (-)
AKR/J MGP_AKRJ_G0034910
 protein coding gene Chr9:69656515-69738893 (-)
BALB/cJ MGP_BALBcJ_G0034973
 protein coding gene Chr9:67772979-67847997 (-)
C3H/HeJ MGP_C3HHeJ_G0034682
 protein coding gene Chr9:70187293-70261824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035492
 protein coding gene Chr9:72368823-72452383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032403
 protein coding gene Chr9:67604854-67674439 (-)
CAST/EiJ MGP_CASTEiJ_G0034004
 protein coding gene Chr9:70454475-70534787 (-)
CBA/J MGP_CBAJ_G0034655
 protein coding gene Chr9:74894015-74973104 (-)
DBA/2J MGP_DBA2J_G0034814
 protein coding gene Chr9:67795138-67874928 (-)
FVB/NJ MGP_FVBNJ_G0034756
 protein coding gene Chr9:67119888-67199193 (-)
LP/J MGP_LPJ_G0034895
 protein coding gene Chr9:70737182-70819408 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034797
 protein coding gene Chr9:75971244-76054202 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035514
 protein coding gene Chr9:69818763-69896213 (-)
PWK/PhJ MGP_PWKPhJ_G0033708
 protein coding gene Chr9:68034886-68116702 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033541
 protein coding gene Chr9:70109808-70187461 (-)
WSB/EiJ MGP_WSBEiJ_G0034116
 protein coding gene Chr9:69708008-69791100 (-)



Homology
more
  • Human Ortholog
    RNF111, ring finger protein 111
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF111, ring finger protein 111
  • Synonyms
    ARK, hRNF111
  • Links
    NCBI Gene ID: 54778
    neXtProt AC: NX_Q6ZNA4
    UniProt: Q6ZNA4

  • Chr Location
    15q22.1-q22.2; chr15:58865175-59097419 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele fail to develop anterior structures and midline with failure to develop anterior endoderm, node and mesendoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    57
  • cDNA Data
    17
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032217 Ensembl Gene Model | MGI Sequence Detail 78302 C57BL/6J ±  kb
    transcript ENSMUST00000113595 Ensembl | MGI Sequence Detail 4735 Not Applicable  
    polypeptide ENSMUSP00000109225 Ensembl | MGI Sequence Detail 989 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:10931 Hara Y, et al., Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res. 1990 Oct;8(4):319-24
    • Latest
      J:314220 Xu H, et al., Arkadia-SKI/SnoN signaling differentially regulates TGF-beta-induced iTreg and Th17 cell differentiation. J Exp Med. 2021 Nov 1;218(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory