Sgca<tm1Kcam> Targeted Allele Detail MGI Mouse (MGI:1934922)

Sgca^tm1Kcam
Targeted Allele Detail

Summary

Symbol:	Sgca^tm1Kcam
Name:	sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell
MGI ID:	MGI:1934922
Synonyms:	alphaSG^-, KO/KO, Sgca^null, Sgca^tm594Kcam
Gene:	Sgca Location: Chr11:94853617-94867153 bp, - strand Genetic Position: Chr11, 59.01 cM, cytoband C
Alliance:	Sgca^tm1Kcam page

Sgca^tm1Kcam/Sgca^tm1Kcam mice display a progressive muscular dystrophy

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:49992
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Replacement of 902 bp including exons 2 and 3 with a neomycin cassette. No mRNA was detectable in Northern blots of total RNA derived from skeletal muscle tissue of homozygous mutants, and no protein was detected in Western blots in membrane enriched preparations of skeletal muscle. (J:49992)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available
Carrying any Sgca Mutation:	26 strains or lines available

References

Original:	J:49992 Duclos F, et al., Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. J Cell Biol. 1998 Sep 21;142(6):1461-71
All:	32 reference(s)

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