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Sirt1 Gene Detail
Summary
  • Symbol
    Sirt1
  • Name
    sirtuin 1
  • Synonyms
    Sir2, Sir2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135607
    NCBI Gene: 93759
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63154784-63174814 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135607
 protein coding gene Chr10:63154784-63217483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017315
 protein coding gene Chr10:62839119-62873881 (-)
A/J MGP_AJ_G0017293
 protein coding gene Chr10:60869258-60938154 (-)
AKR/J MGP_AKRJ_G0017253
 protein coding gene Chr10:62483470-62554127 (-)
BALB/cJ MGP_BALBcJ_G0017253
 protein coding gene Chr10:60980494-61044703 (-)
C3H/HeJ MGP_C3HHeJ_G0017076
 protein coding gene Chr10:62402906-62474656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017711
 protein coding gene Chr10:65092512-65163403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015401
 protein coding gene Chr10:57798621-57860297 (-)
CAST/EiJ MGP_CASTEiJ_G0016647
 protein coding gene Chr10:62473473-62543181 (-)
CBA/J MGP_CBAJ_G0017048
 protein coding gene Chr10:67573672-67597027 (-)
DBA/2J MGP_DBA2J_G0017153
 protein coding gene Chr10:60144222-60207090 (-)
FVB/NJ MGP_FVBNJ_G0017147
 protein coding gene Chr10:59413730-59481611 (-)
LP/J MGP_LPJ_G0017227
 protein coding gene Chr10:63242223-63316223 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017175
 protein coding gene Chr10:69712301-69780912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017749
 protein coding gene Chr10:62319795-62390244 (-)
PWK/PhJ MGP_PWKPhJ_G0016430
 protein coding gene Chr10:60027692-60093898 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016212
 protein coding gene Chr10:61664391-61732198 (-)
WSB/EiJ MGP_WSBEiJ_G0016711
 protein coding gene Chr10:62285109-62358753 (-)



Homology
more
  • Human Ortholog
    SIRT1, sirtuin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIRT1, sirtuin 1
  • Synonyms
    SIR2, SIR2alpha, SIR2L1
  • Links
    NCBI Gene ID: 23411
    neXtProt AC: NX_Q96EB6
    UniProt: Q96EB6

  • Chr Location
    10q21.3; chr10:67884656-67918390 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Sirt1 mouse models; 1 with human SIRT1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    158 phenotypes from 14 alleles in 16 genetic backgrounds
    70 phenotypes from multigenic genotypes
    1 images
    351 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    335
  • GO References
    69
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    992
  • Tissues
    160
  • cDNA Data
    19
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93759 NCBI Gene Model | MGI Sequence Detail 20031 C57BL/6J ±  kb
    transcript NM_019812 RefSeq | MGI Sequence Detail 3910 C57BL/6  
    polypeptide Q923E4 UniProt | EBI | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143506
    References
    more
    • Summaries
      All 719
      Developmental Gene Expression 31
      Diseases 2
      Gene Ontology 69
      Phenotypes 351
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:357482 Li B, et al., Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease. Neural Regen Res. 2024 Jul 1;19(7):1593-1601
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory