Fgfr3<tm1Led> Targeted Allele Detail MGI Mouse (MGI:2135634)

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Fgfr3^tm1Led
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Fgfr3^tm1Led
Name:	fibroblast growth factor receptor 3; targeted mutation 1, Phillip Leder
MGI ID:	MGI:2135634
Gene:	Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
Alliance:	Fgfr3^tm1Led page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:32105
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Insertion of a neomycin cassette into exon 3. Northern blot analysis did not detect mRNA in the brain or the liver of homozygous mutant mice. (J:32105)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:	54 strains or lines available

References

Original:	J:32105 Deng C, et al., Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996 Mar 22;84(6):911-21
All:	23 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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