Car2<n> Chemically induced Allele Detail MGI Mouse (MGI:2135646)

Car2ⁿ
Chemically induced Allele Detail

Summary

Symbol:	Car2ⁿ
Name:	carbonic anhydrase 2; null
MGI ID:	MGI:2135646
Synonyms:	CAII^-, CA(II)D, Car2^-, Car-2⁰, Car2N
Gene:	Car2 Location: Chr3:14951333-14965830 bp, + strand Genetic Position: Chr3, 3.23 cM
Alliance:	Car2ⁿ page

Morphological changes in the stomach and intestine of Car2ⁿ/Car2ⁿ and Car9^tm1Spas/Car9^tm1Spas mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

DBA/2J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		Mutation details: The result of ENU mutagenesis, the mutation at the Car2 locus is likely a nonsense or missense mutation. Molecular analysis shows that the mutant gene is not deleted but is transcribed. The CAR2 protein could not be detected by immunodiffusion analysis and Southern analysis indicates no detectable rearrangements or polymorphisms. (J:19268)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Car2 Mutation:	21 strains or lines available

References

Original:	J:19268 Lewis SE, et al., N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1962-6
All:	30 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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