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Lmod2 Gene Detail
Summary
  • Symbol
    Lmod2
  • Name
    leiomodin 2 (cardiac)
  • Synonyms
    C-Lmod
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135672
    NCBI Gene: 93677
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:24597770-24605413 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.28 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135672
 protein coding gene Chr6:24597761-24605413 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030496
 protein coding gene Chr6:22163587-22171239 (+)
A/J MGP_AJ_G0030469
 protein coding gene Chr6:21237294-21244941 (+)
AKR/J MGP_AKRJ_G0030396
 protein coding gene Chr6:21916609-21924260 (+)
BALB/cJ MGP_BALBcJ_G0030479
 protein coding gene Chr6:21344678-21352321 (+)
C3H/HeJ MGP_C3HHeJ_G0030192
 protein coding gene Chr6:21917347-21924998 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030933
 protein coding gene Chr6:22864067-22871713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028144
 protein coding gene Chr6:19694058-19701681 (+)
CAST/EiJ MGP_CASTEiJ_G0029594
 protein coding gene Chr6:21772454-21788517 (+)
CBA/J MGP_CBAJ_G0030170
 protein coding gene Chr6:23637590-23645231 (+)
DBA/2J MGP_DBA2J_G0030314
 protein coding gene Chr6:21194780-21202424 (+)
FVB/NJ MGP_FVBNJ_G0030268
 protein coding gene Chr6:20957146-20964790 (+)
LP/J MGP_LPJ_G0030401
 protein coding gene Chr6:22317291-22324876 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030304
 protein coding gene Chr6:25554290-25561994 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030963
 protein coding gene Chr6:21846552-21854195 (+)
PWK/PhJ MGP_PWKPhJ_G0029308
 protein coding gene Chr6:20759748-20767609 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029144
 protein coding gene Chr6:21577286-21593371 (+)
WSB/EiJ MGP_WSBEiJ_G0029670
 protein coding gene Chr6:21814094-21821748 (+)



Homology
more
  • Human Ortholog
    LMOD2, leiomodin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMOD2, leiomodin 2
  • Synonyms
    C-LMOD, CLMOD, CMD2G
  • Links
    NCBI Gene ID: 442721
    neXtProt AC: NX_Q6P5Q4
    UniProt: Q6P5Q4

  • Chr Location
    7
Human Diseases
more
  • Diseases
    1 with Lmod2 mouse models; 1 with human LMOD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in thin filaments in the heart, cardiac contractile dysfunction, abnormal myocardial fiber ultrastucture, dilated cardiomyopathy, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    32
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93677 NCBI Gene Model | MGI Sequence Detail 7644 C57BL/6J ±  kb
    transcript NM_053098 RefSeq | MGI Sequence Detail 1967 C57BL/6  
    polypeptide Q3UHZ5 UniProt | EBI | MGI Sequence Detail 550 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:69533 Conley CA, et al., Leiomodins: larger members of the tropomodulin (tmod) gene family. Genomics. 2001 Apr 15;73(2):127-39
    • Latest
      J:347151 Kuwabara Y, et al., A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2213696120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory