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Entpd7 Gene Detail
Summary
  • Symbol
    Entpd7
  • Name
    ectonucleoside triphosphate diphosphohydrolase 7
  • Synonyms
    1810012B13Rik, 1810020C02Rik, 2810003F23Rik, LALP1, Lysal2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135885
    NCBI Gene: 93685
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43678111-43722136 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.67 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135885
 protein coding gene Chr19:43678111-43722292 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025155
 protein coding gene Chr19:43099850-43151152 (+)
A/J MGP_AJ_G0025132
 protein coding gene Chr19:41050782-41097353 (+)
AKR/J MGP_AKRJ_G0025100
 protein coding gene Chr19:42345912-42393247 (+)
BALB/cJ MGP_BALBcJ_G0025126
 protein coding gene Chr19:41094170-41141334 (+)
C3H/HeJ MGP_C3HHeJ_G0024886
 protein coding gene Chr19:42522842-42576241 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025569
 protein coding gene Chr19:44170000-44216428 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022983
 protein coding gene Chr19:40348375-40391159 (+)
CAST/EiJ MGP_CASTEiJ_G0024351
 protein coding gene Chr19:42217617-42264424 (+)
CBA/J MGP_CBAJ_G0024866
 protein coding gene Chr19:46354415-46410205 (+)
DBA/2J MGP_DBA2J_G0024998
 protein coding gene Chr19:40878864-40923686 (+)
FVB/NJ MGP_FVBNJ_G0024959
 protein coding gene Chr19:40633346-40679359 (+)
LP/J MGP_LPJ_G0025084
 protein coding gene Chr19:43067968-43117146 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024990
 protein coding gene Chr19:45901725-45954386 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025627
 protein coding gene Chr19:42440674-42490713 (+)
PWK/PhJ MGP_PWKPhJ_G0024100
 protein coding gene Chr19:40776210-40822446 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023904
 protein coding gene Chr19:41150039-41207890 (+)
WSB/EiJ MGP_WSBEiJ_G0024421
 protein coding gene Chr19:42578078-42626740 (+)



Homology
more
  • Human Ortholog
    ENTPD7, ectonucleoside triphosphate diphosphohydrolase 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENTPD7, ectonucleoside triphosphate diphosphohydrolase 7
  • Synonyms
    LALP1
  • Links
    NCBI Gene ID: 57089
    neXtProt AC: NX_Q9NQZ7
    UniProt: Q9NQZ7

  • Chr Location
    10q24.2; chr10:99659509-99711241 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deletions in this gene have increased Th17 T cell levels in the lamina propria of the small intestine. They show increased resistance to Citrobacter rodentium infection and increased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025192 Ensembl Gene Model | MGI Sequence Detail 44026 C57BL/6J ±  kb
    transcript ENSMUST00000081079 Ensembl | MGI Sequence Detail 5911 Not Applicable  
    polypeptide ENSMUSP00000079864 Ensembl | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916337, MGI:1916350, MGI:1923796
    References
    more
    • Summaries
      All 33
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:191188 Kusu T, et al., Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 2013 Jan 15;190(2):774-83
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory