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Ccr4tm1Pwr
Targeted Allele Detail
Summary
Symbol: Ccr4tm1Pwr
Name: C-C motif chemokine receptor 4; targeted mutation 1, Christine Power
MGI ID: MGI:2136258
Synonyms: Ccr4-, CCR4-
Gene: Ccr4  Location: Chr9:114319384-114333984 bp, - strand  Genetic Position: Chr9, 64.49 cM
Alliance: Ccr4tm1Pwr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70088
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced the entire coding sequence and part of the 5' noncoding region. RT-PCR did not amplify transcript from thymus, spleen, or peritoneal macrophage cells of homozygous mutant mice. (J:70088)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr4 Mutation:  30 strains or lines available
References
Original:  J:70088 Chvatchko Y, et al., A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med. 2000 May 15;191(10):1755-64
All:  44 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory