About   Help   FAQ
Crb1 Gene Detail
Summary
  • Symbol
    Crb1
  • Name
    crumbs family member 1, photoreceptor morphogenesis associated
  • Synonyms
    7530426H14Rik, A930008G09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136343
    NCBI Gene: 170788
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:139124794-139304838 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 60.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4793 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136343
 protein coding gene Chr1:139101288-139307262 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016551
 protein coding gene Chr1:143248885-143437917 (-)
A/J MGP_AJ_G0016534
 protein coding gene Chr1:137681434-137863265 (-)
AKR/J MGP_AKRJ_G0016499
 protein coding gene Chr1:141839153-142030584 (-)
BALB/cJ MGP_BALBcJ_G0016494
 protein coding gene Chr1:138036583-138223577 (-)
C3H/HeJ MGP_C3HHeJ_G0016320
 protein coding gene Chr1:141924857-142116663 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016955
 protein coding gene Chr1:148277492-148469260 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014666
 protein coding gene Chr1:130744356-130922245 (-)
CAST/EiJ MGP_CASTEiJ_G0015900
 protein coding gene Chr1:141092105-141285340 (-)
CBA/J MGP_CBAJ_G0016293
 protein coding gene Chr1:153383294-153592946 (-)
DBA/2J MGP_DBA2J_G0016399
 protein coding gene Chr1:136692672-136869883 (-)
FVB/NJ MGP_FVBNJ_G0016398
 protein coding gene Chr1:135320190-135505175 (-)
LP/J MGP_LPJ_G0016470
 protein coding gene Chr1:144345102-144531278 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016423
 protein coding gene Chr1:159041971-159237682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016991
 protein coding gene Chr1:141631041-141827294 (-)
PWK/PhJ MGP_PWKPhJ_G0015686
 protein coding gene Chr1:135760659-135942719 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015473
 protein coding gene Chr1:140581581-140767612 (-)
WSB/EiJ MGP_WSBEiJ_G0015963
 protein coding gene Chr1:141636580-141826946 (-)



Homology
more
  • Human Ortholog
    CRB1, crumbs cell polarity complex component 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRB1, crumbs cell polarity complex component 1
  • Synonyms
    CRB1-A, CRB1-B, CRB1-C, LCA8, RP12
  • Links
    NCBI Gene ID: 23418
    neXtProt AC: NX_P82279
    UniProt: P82279

  • Chr Location
    1q31.3; chr1:197201504-197478455 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Crb1 mouse models; 6 with human CRB1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 9 alleles in 10 genetic backgrounds
    41 phenotypes from multigenic genotypes
    2 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show focal retinal lesions, loss of adherens junctions between photoreceptors and Muller glia cells, and light-accelerated retinal degeneration. Homozygotes for a spontaneous allele show background-sensitive retinal spotting, photoreceptor dysplasia and degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    155
  • cDNA Data
    34
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063681 Ensembl Gene Model | MGI Sequence Detail 180045 C57BL/6J ±  kb
    transcript ENSMUST00000059825 Ensembl | MGI Sequence Detail 5901 Not Applicable  
    polypeptide ENSMUSP00000060769 Ensembl | MGI Sequence Detail 1405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 34
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442131, MGI:2443401
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 17
      Diseases 3
      Gene Ontology 14
      Phenotypes 102
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354796 Cho SH, et al., Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model. Dev Biol. 2024 Sep 14;517:39-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory