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Sarm1 Gene Detail
Summary
  • Symbol
    Sarm1
  • Name
    sterile alpha and HEAT/Armadillo motif containing 1
  • Synonyms
    A830091I15Rik, MyD88-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136419
    NCBI Gene: 237868
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78363156-78388580 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    740 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136419
 protein coding gene Chr11:78361099-78388642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018781
 protein coding gene Chr11:79485614-79516212 (-)
A/J MGP_AJ_G0018747
 protein coding gene Chr11:76443030-76468842 (-)
AKR/J MGP_AKRJ_G0018717
 protein coding gene Chr11:78745434-78772504 (-)
BALB/cJ MGP_BALBcJ_G0018721
 protein coding gene Chr11:76846685-76871947 (-)
C3H/HeJ MGP_C3HHeJ_G0018534
 protein coding gene Chr11:78793308-78819450 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019172
 protein coding gene Chr11:81956661-81985038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016807
 protein coding gene Chr11:73413815-73438765 (-)
CAST/EiJ MGP_CASTEiJ_G0018088
 protein coding gene Chr11:79249595-79276245 (-)
CBA/J MGP_CBAJ_G0018505
 protein coding gene Chr11:85563865-85595046 (-)
DBA/2J MGP_DBA2J_G0018613
 protein coding gene Chr11:76016251-76043531 (-)
FVB/NJ MGP_FVBNJ_G0018603
 protein coding gene Chr11:75605232-75633773 (-)
LP/J MGP_LPJ_G0018684
 protein coding gene Chr11:80003983-80031126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018629
 protein coding gene Chr11:85930836-85956221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019212
 protein coding gene Chr11:78994375-79020549 (-)
PWK/PhJ MGP_PWKPhJ_G0017859
 protein coding gene Chr11:76814680-76839995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017650
 protein coding gene Chr11:78605536-78637054 (-)
WSB/EiJ MGP_WSBEiJ_G0018141
 protein coding gene Chr11:78823898-78849263 (-)



Homology
more
  • Human Ortholog
    SARM1, sterile alpha and TIR motif containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SARM1, sterile alpha and TIR motif containing 1
  • Synonyms
    hSARM1, HsTIR, MyD88-5, SAMD2, SARM
  • Links
    NCBI Gene ID: 23098
    neXtProt AC: NX_Q6SZW1
    UniProt: Q6SZW1

  • Chr Location
    17q11.2; chr17:28364356-28404049 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced apoptosis induced by oxygen and glucose deprivation in hippocampal slices.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    49
  • cDNA Data
    40
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050132 Ensembl Gene Model | MGI Sequence Detail 25425 C57BL/6J ±  kb
    transcript ENSMUST00000108287 Ensembl | MGI Sequence Detail 4868 Not Applicable  
    polypeptide ENSMUSP00000103922 Ensembl | MGI Sequence Detail 764 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144643
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 7
      Gene Ontology 16
      Phenotypes 89
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354314 Hinz FI, et al., Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. J Neurosci. 2024 Jun 12;44(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory