Ren1<tm1Afu> Targeted Allele Detail MGI Mouse (MGI:2136642)

Ren1^tm1Afu
Targeted Allele Detail

Summary

Symbol:	Ren1^tm1Afu
Name:	renin 1 structural; targeted mutation 1, Akiyoshi Fukamizu
MGI ID:	MGI:2136642
Synonyms:	renin-
Gene:	Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
Alliance:	Ren1^tm1Afu page

Ren1^tm1Afu/Ren1^tm1Afu mice exhibit kidney abnormalities

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:59299
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A lacZ-neomycin reistance cassette replaced the first three exons. Northern blot analysis of kidney did not detect RNA in homozygous mutant mice. (J:59299)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Ren1 Mutation:	35 strains or lines available

References

Original:	J:59299 Yanai K, et al., Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem. 2000 Jan 7;275(1):5-8
All:	3 reference(s)

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