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Gfra3tm1Hmd
Targeted Allele Detail
Summary
Symbol: Gfra3tm1Hmd
Name: glial cell line derived neurotrophic factor family receptor alpha 3; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:2136781
Gene: Gfra3  Location: Chr18:34822951-34853440 bp, - strand  Genetic Position: Chr18, 18.69 cM
Alliance: Gfra3tm1Hmd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57342
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Replacement of exons 4 through 8 with a neomycin cassette. No mRNA was detected in ganglia of homozygous mutant embryos, as assayed by in situ hybridization. (J:57342)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gfra3 Mutation:  33 strains or lines available
References
Original:  J:57342 Nishino J, et al., GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Neuron. 1999 Aug;23(4):725-36
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory