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Dvl1tm1Awb
Targeted Allele Detail
Summary
Symbol: Dvl1tm1Awb
Name: dishevelled segment polarity protein 1; targeted mutation 1, Anthony Wynshaw-Boris
MGI ID: MGI:2137230
Synonyms: Dvl1-, Dvl1del131-225
Gene: Dvl1  Location: Chr4:155931859-155943760 bp, + strand  Genetic Position: Chr4, 87.61 cM
Alliance: Dvl1tm1Awb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42758
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of exon 2 and exons 3 and 4, which encode amino acids 131-225. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was produced from this allele. (J:42758)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dvl1 Mutation:  35 strains or lines available
References
Original:  J:42758 Lijam N, et al., Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell. 1997 Sep 5;90(5):895-905
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory