Ephx1tm1Gonz
Targeted Allele Detail
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| Symbol: |
Ephx1tm1Gonz |
| Name: |
epoxide hydrolase 1, microsomal; targeted mutation 1, Frank J Gonzalez |
| MGI ID: |
MGI:2137236 |
| Synonyms: |
mEH- |
| Gene: |
Ephx1 Location: Chr1:180817121-180845134 bp, - strand Genetic Position: Chr1, 84.48 cM
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| Alliance: |
Ephx1tm1Gonz page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:56886
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced 0.7 kb of sequence containing part of exon 2. Northern blot analysis detected a shorter mRNA transcript produced by this allele. However, western blot analysis of extracts of liver microsomes derived from homozygous mice did not detect any encoded protein.
(J:56886)
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View phenotypes and curated references for all genotypes (concatenated display).
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The ES cell line, purchased from Genome Systems (St. Louis), was derived from 129X1/Sv. The name of the line was not specified.
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| Original: |
J:56886 Miyata M, et al., Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J Biol Chem. 1999 Aug 20;274(34):23963-8 |
| All: |
5 reference(s) |
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Analysis Tools
