Gabra1<tm1.1Geh> Targeted Allele Detail MGI Mouse (MGI:2137421)

Gabra1^tm1.1Geh
Targeted Allele Detail

Summary

Symbol:	Gabra1^tm1.1Geh
Name:	gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1.1, Gregg E Homanics
MGI ID:	MGI:2137421
Synonyms:	alpha1^-, alpha1⁰
Gene:	Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
Alliance:	Gabra1^tm1.1Geh page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70505
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: This allele is a derivative of Gabra1^tm1Geh in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying a ubiquitously expressed Cre recombinase. (J:70505)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:	48 strains or lines available

References

Original:	J:70505 Vicini S, et al., GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci. 2001 May 1;21(9):3009-16
All:	24 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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