Rab23<opb2> Chemically induced Allele Detail MGI Mouse (MGI:2137533)

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Rab23^opb2
Chemically induced Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Rab23^opb2
Name:	RAB23, member RAS oncogene family; open brain 2
MGI ID:	MGI:2137533
Synonyms:	opb²
Gene:	Rab23 Location: Chr1:33758991-33781642 bp, + strand Genetic Position: Chr1, 12.8 cM
Alliance:	Rab23^opb2 page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: ENU treatment induced a C-to-T mutation at position 238 of the encoded mRNA that altered codon 80 from an arginine to a stop codon (p.R80). If the peptide is translated, it will lack the domains required for guanine nucleotide and Rab effector binding. (J:70423*)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	97 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rab23 Mutation:	33 strains or lines available

References

Original:	J:48268 Kasarskis A, et al., A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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