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Sfxn5 Gene Detail
Summary
  • Symbol
    Sfxn5
  • Name
    sideroflexin 5
  • Synonyms
    C230001H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137681
    NCBI Gene: 94282
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85190031-85310404 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.23 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2508 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137681
 protein coding gene Chr6:85190031-85310488 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030950
 protein coding gene Chr6:86353830-86484494 (-)
A/J MGP_AJ_G0030919
 protein coding gene Chr6:83071617-83195604 (-)
AKR/J MGP_AKRJ_G0030847
 protein coding gene Chr6:85475501-85599935 (-)
BALB/cJ MGP_BALBcJ_G0030929
 protein coding gene Chr6:83064299-83186585 (-)
C3H/HeJ MGP_C3HHeJ_G0030781
 protein coding gene Chr6:98836625-98961343 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031389
 protein coding gene Chr6:88749490-88874932 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028574
 protein coding gene Chr6:81354728-81474085 (-)
CAST/EiJ MGP_CASTEiJ_G0030038
 protein coding gene Chr6:85498837-85621503 (-)
CBA/J MGP_CBAJ_G0030616
 protein coding gene Chr6:92247967-92368721 (-)
DBA/2J MGP_DBA2J_G0030769
 protein coding gene Chr6:82356042-82480894 (-)
FVB/NJ MGP_FVBNJ_G0030722
 protein coding gene Chr6:81559480-81684519 (-)
LP/J MGP_LPJ_G0030848
 protein coding gene Chr6:86354768-86485828 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030758
 protein coding gene Chr6:96430579-96558904 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031413
 protein coding gene Chr6:85285409-85409279 (-)
PWK/PhJ MGP_PWKPhJ_G0029753
 protein coding gene Chr6:81290204-81416824 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029581
 protein coding gene Chr6:84141093-84264459 (-)
WSB/EiJ MGP_WSBEiJ_G0030119
 protein coding gene Chr6:85726415-85852146 (-)



Homology
more
  • Human Ortholog
    SFXN5, sideroflexin 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFXN5, sideroflexin 5
  • Synonyms
    BBG-TCC, SLC56A5
  • Links
    NCBI Gene ID: 94097
    neXtProt AC: NX_Q8TD22
    UniProt: Q8TD22

  • Chr Location
    2p13.2; chr2:72942036-73075619 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    42
  • cDNA Data
    26
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033720 Ensembl Gene Model | MGI Sequence Detail 120374 C57BL/6J ±  kb
transcript ENSMUST00000045846 Ensembl | MGI Sequence Detail 3656 Not Applicable  
polypeptide ENSMUSP00000041872 Ensembl | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444397
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:68377 Fleming MD, et al., A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001 Mar 15;15(6):652-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory