Mme<tm1Cge> Targeted Allele Detail MGI Mouse (MGI:2137696)

Mme^tm1Cge
Targeted Allele Detail

Summary

Symbol:	Mme^tm1Cge
Name:	membrane metallo endopeptidase; targeted mutation 1, Craig Gerard
MGI ID:	MGI:2137696
Synonyms:	NEP-
Gene:	Mme Location: Chr3:63202632-63291134 bp, + strand Genetic Position: Chr3, 29.97 cM
Alliance:	Mme^tm1Cge page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70516
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced 0.6kb of sequence containing exon 13 and part of intron 13. Northern blot analysis using a cDNA probe for the active site region, exons 14 - 20, did not detect message in renal tissue from homozygous mutant pups. (J:70516)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mme Mutation:	61 strains or lines available

References

Original:	J:70516 Lu B, et al., Neutral endopeptidase modulation of septic shock. J Exp Med. 1995 Jun 1;181(6):2271-5
All:	33 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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