Ptger1<tm1Sna> Targeted Allele Detail MGI Mouse (MGI:2137762)

Ptger1^tm1Sna
Targeted Allele Detail

Summary

Symbol:	Ptger1^tm1Sna
Name:	prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Shuh Narumiya
MGI ID:	MGI:2137762
Synonyms:	EP1-, Ptger1-
Gene:	Ptger1 Location: Chr8:84393307-84399382 bp, + strand Genetic Position: Chr8, 40.22 cM
Alliance:	Ptger1^tm1Sna page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70534
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Insertion of a neomycin resistance cassette into the FspI site of exon 2, located immediately before the sequence encoding the first transmembrane domain. Northern blots of renal tissue did not detect Ptger1 transcript in homozygous mutant mice. (J:70534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Ptger1^tm1Sna

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ptger1 Mutation:	22 strains or lines available

References

Original:	J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:	46 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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