Mapt<tm1Noh> Targeted Allele Detail MGI Mouse (MGI:2138030)

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Mapt^tm1Noh
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Mapt^tm1Noh
Name:	microtubule-associated protein tau; targeted mutation 1, Nobutaka Hirokawa
MGI ID:	MGI:2138030
Synonyms:	tau-
Gene:	Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapt^tm1Noh page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:19030
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A PGK-neomycin cassette was inserted into exon 1 of the gene. Mapt protein was not detected by Western blot using anti-Mapt antibodies in crude extracts from cerebrum and cerebellum or the dorsal root ganglia of homozygous mutant mice. (J:19030)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mapt Mutation:	430 strains or lines available

References

Original:	J:19030 Harada A, et al., Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 1994 Jun 9;369(6480):488-91
All:	6 reference(s)

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