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Lbr Gene Detail
Summary
  • Symbol
    Lbr
  • Name
    lamin B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138281
    NCBI Gene: 98386
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:181642880-181669933 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.89 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138281
 protein coding gene Chr1:181642880-181670611 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016888
 protein coding gene Chr1:188377504-188406829 (-)
A/J MGP_AJ_G0016867
 protein coding gene Chr1:180732611-180762418 (-)
AKR/J MGP_AKRJ_G0016833
 protein coding gene Chr1:186108661-186137071 (-)
BALB/cJ MGP_BALBcJ_G0016825
 protein coding gene Chr1:181369640-181398085 (-)
C3H/HeJ MGP_C3HHeJ_G0016650
 protein coding gene Chr1:186891616-186925351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017288
 protein coding gene Chr1:194487138-194515752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014995
 protein coding gene Chr1:171692024-171719341 (-)
CAST/EiJ MGP_CASTEiJ_G0016231
 protein coding gene Chr1:186243351-186284185 (-)
CBA/J MGP_CBAJ_G0016624
 protein coding gene Chr1:201675176-201722267 (-)
DBA/2J MGP_DBA2J_G0016730
 protein coding gene Chr1:179540681-179568527 (-)
FVB/NJ MGP_FVBNJ_G0016726
 protein coding gene Chr1:177661081-177686621 (-)
LP/J MGP_LPJ_G0016804
 protein coding gene Chr1:189604878-189632421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016757
 protein coding gene Chr1:208762565-208793310 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017325
 protein coding gene Chr1:185908651-185937497 (-)
PWK/PhJ MGP_PWKPhJ_G0016019
 protein coding gene Chr1:178696962-178726637 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015795
 protein coding gene Chr1:184856467-184886587 (-)
WSB/EiJ MGP_WSBEiJ_G0016294
 protein coding gene Chr1:186098833-186127820 (-)



Homology
more
  • Human Ortholog
    LBR, lamin B receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LBR, lamin B receptor
  • Synonyms
    C14SR, DHCR14B, LMN2R, PHA, PHASK, TDRD18
  • Links
    NCBI Gene ID: 3930
    neXtProt AC: NX_Q14739
    UniProt: Q14739

  • Chr Location
    1q42.12; chr1:225401502-225428925 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Lbr mouse models; 3 with human LBR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    110 phenotypes from 7 alleles in 9 genetic backgrounds
    15 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal skin and hair and impair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    40
  • cDNA Data
    176
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98386 NCBI Gene Model | MGI Sequence Detail 27054 C57BL/6J ±  kb
    transcript NM_001421194 RefSeq | MGI Sequence Detail 4059 ZRU/MplStud  
    polypeptide Q3U9G9 UniProt | EBI | MGI Sequence Detail 626 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 176
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11144, MGI:96390
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 15
      Phenotypes 44
    • Earliest
      J:13065 Carter TC, et al., Ichthyosis, a new recessive mutant in the house mouse. J Hered. 1950;41(11):297-300
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory