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Golga2 Gene Detail
Summary
  • Symbol
    Golga2
  • Name
    golgin A2
  • Synonyms
    GM130
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139395
    NCBI Gene: 99412
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32178299-32197925 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139395
 protein coding gene Chr2:32177396-32197933 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025601
 protein coding gene Chr2:30732592-30753187 (+)
A/J MGP_AJ_G0025520
 protein coding gene Chr2:26834761-29450455 (+)
AKR/J MGP_AKRJ_G0025548
 protein coding gene Chr2:30473879-30499305 (+)
BALB/cJ MGP_BALBcJ_G0025575
 protein coding gene Chr2:29555729-29577276 (+)
C3H/HeJ MGP_C3HHeJ_G0025277
 protein coding gene Chr2:27662907-30394087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025960
 protein coding gene Chr2:28831323-31691277 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023428
 protein coding gene Chr2:28157824-28178657 (+)
CAST/EiJ MGP_CASTEiJ_G0024740
 protein coding gene Chr2:27555585-30330055 (+)
CBA/J MGP_CBAJ_G0025313
 protein coding gene Chr2:32851875-32889331 (+)
DBA/2J MGP_DBA2J_G0025446
 protein coding gene Chr2:29197494-29218390 (+)
FVB/NJ MGP_FVBNJ_G0025350
 protein coding gene Chr2:26434399-29091258 (+)
LP/J MGP_LPJ_G0025532
 protein coding gene Chr2:30605748-30627536 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025439
 protein coding gene Chr2:32519563-32544794 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026019
 protein coding gene Chr2:27653331-30380612 (+)
PWK/PhJ MGP_PWKPhJ_G0024545
 protein coding gene Chr2:29101971-29123165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024345
 protein coding gene Chr2:30515509-30536154 (+)
WSB/EiJ MGP_WSBEiJ_G0024866
 protein coding gene Chr2:30531465-30551997 (+)



Homology
more
  • Human Ortholog
    GOLGA2, golgin A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOLGA2, golgin A2
  • Synonyms
    DEDHMB, GM130
  • Links
    NCBI Gene ID: 2801
    neXtProt AC: NX_Q08379
    UniProt: Q08379

  • Chr Location
    9q34.11; chr9:128255829-128276026 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 3 alleles in 5 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show premature death, developmental delay, ataxia, Purkinje neuron loss, and male infertility with globozoospermia and lack of acrosome formation. Homozygotes for a different null allele show partial prenatal lethality and autophagy-induced liver and lung fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    46
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    30
  • cDNA Data
    115
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 99412 NCBI Gene Model | MGI Sequence Detail 19627 C57BL/6J ±  kb
    transcript NM_133852 RefSeq | MGI Sequence Detail 4361 C57BL/6  
    polypeptide Q921M4 UniProt | EBI | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 115

      Microarray probesets 3
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 87
      Gene Ontology 46
      Phenotypes 11
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:358091 Arriagada C, et al., Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development. Dev Cell. 2024 Oct 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory