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Duox1 Gene Detail
Summary
  • Symbol
    Duox1
  • Name
    dual oxidase 1
  • Synonyms
    9930101G15Rik, LNOX1, NOXEF1, THOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139422
    NCBI Gene: 99439
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122146153-122178453 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    778 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139422
 protein coding gene Chr2:122143525-122178454 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026413
 protein coding gene Chr2:125317256-125348516 (+)
A/J MGP_AJ_G0026375
 protein coding gene Chr2:120191667-120223249 (+)
AKR/J MGP_AKRJ_G0026352
 protein coding gene Chr2:123558211-123592633 (+)
BALB/cJ MGP_BALBcJ_G0026387
 protein coding gene Chr2:120421383-120454133 (+)
C3H/HeJ MGP_C3HHeJ_G0026132
 protein coding gene Chr2:124040596-124074925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026834
 protein coding gene Chr2:129383664-129417596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024213
 protein coding gene Chr2:115161641-115193869 (+)
CAST/EiJ MGP_CASTEiJ_G0025594
 protein coding gene Chr2:124381861-124466810 (+)
CBA/J MGP_CBAJ_G0026111
 protein coding gene Chr2:133933907-133974476 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0026210
 protein coding gene Chr2:118380943-118412972 (+)
LP/J MGP_LPJ_G0026350
 protein coding gene Chr2:125562534-125595344 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026230
 protein coding gene Chr2:138144445-138178492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026889
 protein coding gene Chr2:123675440-123708210 (+)
PWK/PhJ MGP_PWKPhJ_G0025330
 protein coding gene Chr2:119202050-119289781 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025130
 protein coding gene Chr2:122818687-122911498 (+)
WSB/EiJ MGP_WSBEiJ_G0025666
 protein coding gene Chr2:124536347-124569297 (+)



Homology
more
  • Human Ortholog
    DUOX1, dual oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUOX1, dual oxidase 1
  • Synonyms
    LNOX1, NOXEF1, THOX1
  • Links
    NCBI Gene ID: 53905
    neXtProt AC: NX_Q9NRD9
    UniProt: Q9NRD9

  • Chr Location
    15q21.1; chr15:45129933-45165576 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    24 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Duox1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    79 strains or lines available
Mice homozygous for an ENU-induced allele exhibit normal skeletal development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    103
  • cDNA Data
    20
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033268 Ensembl Gene Model | MGI Sequence Detail 32301 C57BL/6J ±  kb
transcript ENSMUST00000099461 Ensembl | MGI Sequence Detail 5267 Not Applicable  
polypeptide ENSMUSP00000097060 Ensembl | MGI Sequence Detail 1551 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 20
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory