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Lao1 Gene Detail
Summary
  • Symbol
    Lao1
  • Name
    L-amino acid oxidase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140628
    NCBI Gene: 100470
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118819164-118826107 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140628
 protein coding gene Chr4:118818775-118826109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028686
 protein coding gene Chr4:120110995-120118313 (+)
A/J MGP_AJ_G0028646
 protein coding gene Chr4:115408368-115415722 (+)
AKR/J MGP_AKRJ_G0028599
 protein coding gene Chr4:117921107-117928431 (+)
BALB/cJ MGP_BALBcJ_G0028669
 protein coding gene Chr4:116027954-116035256 (+)
C3H/HeJ MGP_C3HHeJ_G0028384
 protein coding gene Chr4:119479528-119486830 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029110
 protein coding gene Chr4:124688570-124695904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026387
 protein coding gene Chr4:109518422-109525635 (+)
CAST/EiJ MGP_CASTEiJ_G0027815
 protein coding gene Chr4:116792991-116800234 (+)
CBA/J MGP_CBAJ_G0028351
 protein coding gene Chr4:128051814-128059116 (+)
DBA/2J MGP_DBA2J_G0028498
 protein coding gene Chr4:116001600-116008950 (+)
FVB/NJ MGP_FVBNJ_G0028464
 protein coding gene Chr4:114512211-114521106 (+)
LP/J MGP_LPJ_G0028598
 protein coding gene Chr4:120231466-120238787 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028492
 protein coding gene Chr4:132943729-132951083 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029147
 protein coding gene Chr4:118993465-119000777 (+)
PWK/PhJ MGP_PWKPhJ_G0027538
 protein coding gene Chr4:112920198-112927611 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027364
 protein coding gene Chr4:115402706-115409924 (+)
WSB/EiJ MGP_WSBEiJ_G0027895
 protein coding gene Chr4:118990191-118997503 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show alterations in the free amino acid composition and antibacterial activity of milk and increased susceptibility to intramammary bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    246
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100470 NCBI Gene Model | MGI Sequence Detail 6944 C57BL/6J ±  kb
    transcript NM_133892 RefSeq | MGI Sequence Detail 1958 C57BL/6  
    polypeptide NP_598653 RefSeq | MGI Sequence Detail 523 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      cDNA 246

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:76851 Sun Y, et al., Characterization and expression of L-amino acid oxidase of mouse milk. J Biol Chem. 2002 May 24;277(21):19080-6
    • Latest
      J:307377 Zhang H, et al., L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls. Biol Reprod. 2021 May 7;104(5):1154-1161
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory