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Napepld Gene Detail
Summary
  • Symbol
    Napepld
  • Name
    N-acyl phosphatidylethanolamine phospholipase D
  • Synonyms
    NAPE-PLD
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140885
    NCBI Gene: 242864
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21867899-21906394 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140885
 protein coding gene Chr5:21867899-21906620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029321
 protein coding gene Chr5:19231283-19278863 (-)
A/J MGP_AJ_G0029286
 protein coding gene Chr5:18601645-18643543 (-)
AKR/J MGP_AKRJ_G0029237
 protein coding gene Chr5:19314887-19361981 (-)
BALB/cJ MGP_BALBcJ_G0029298
 protein coding gene Chr5:19038959-19077855 (-)
C3H/HeJ MGP_C3HHeJ_G0029017
 protein coding gene Chr5:19383016-19426016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029751
 protein coding gene Chr5:20635926-20677826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026990
 protein coding gene Chr5:16655051-16692566 (-)
CAST/EiJ MGP_CASTEiJ_G0028429
 protein coding gene Chr5:18710597-18754618 (-)
CBA/J MGP_CBAJ_G0028984
 protein coding gene Chr5:20867543-20913508 (-)
DBA/2J MGP_DBA2J_G0029136
 protein coding gene Chr5:18885076-18926759 (-)
FVB/NJ MGP_FVBNJ_G0029094
 protein coding gene Chr5:18291584-18331269 (-)
LP/J MGP_LPJ_G0029220
 protein coding gene Chr5:19635497-19684423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029122
 protein coding gene Chr5:22138448-22181853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029784
 protein coding gene Chr5:18969060-19011055 (-)
PWK/PhJ MGP_PWKPhJ_G0028152
 protein coding gene Chr5:17939581-17981886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027985
 protein coding gene Chr5:18333235-18380598 (-)
WSB/EiJ MGP_WSBEiJ_G0028509
 protein coding gene Chr5:19034718-19077051 (-)



Homology
more
  • Human Ortholog
    NAPEPLD, N-acyl phosphatidylethanolamine phospholipase D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAPEPLD, N-acyl phosphatidylethanolamine phospholipase D
  • Synonyms
    C7orf18, FMP30, NAPE-PLD
  • Links
    NCBI Gene ID: 222236
    neXtProt AC: NX_Q6IQ20
    UniProt: Q6IQ20

  • Chr Location
    7q22.1; chr7:103099776-103150001 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and healthy, but have abnormal brain levels of N-acyl ethanolamines and N-acyl phosphatidylethanolamines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044968 Ensembl Gene Model | MGI Sequence Detail 38496 C57BL/6J ±  kb
    transcript ENSMUST00000115217 Ensembl | MGI Sequence Detail 3954 Not Applicable  
    polypeptide ENSMUSP00000110872 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010983 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
      (term hierarchy)
    • EC
      3.1.4.54
    • InterPro Domains
      IPR001279 Metallo-beta-lactamase
      IPR024884 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D
      IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 14
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:350913 Tevosian M, et al., NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Transl Psychiatry. 2023 May 6;13(1):152
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory