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Mapkapk3 Gene Detail
Summary
  • Symbol
    Mapkapk3
  • Name
    mitogen-activated protein kinase-activated protein kinase 3
  • Synonyms
    MK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143163
    NCBI Gene: 102626
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107132126-107167076 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    963 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143163
 protein coding gene Chr9:107132125-107167082 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035248
 protein coding gene Chr9:109111335-109146256 (-)
A/J MGP_AJ_G0035227
 protein coding gene Chr9:105149671-105185525 (-)
AKR/J MGP_AKRJ_G0035159
 protein coding gene Chr9:107769645-107808850 (-)
BALB/cJ MGP_BALBcJ_G0035221
 protein coding gene Chr9:104818826-104854723 (-)
C3H/HeJ MGP_C3HHeJ_G0034931
 protein coding gene Chr9:108168412-108206378 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035741
 protein coding gene Chr9:112106568-112147552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032639
 protein coding gene Chr9:102578926-102614319 (-)
CAST/EiJ MGP_CASTEiJ_G0034242
 protein coding gene Chr9:108094983-108136497 (-)
CBA/J MGP_CBAJ_G0034899
 protein coding gene Chr9:116084784-116119742 (-)
DBA/2J MGP_DBA2J_G0035060
 protein coding gene Chr9:104602205-104644551 (-)
FVB/NJ MGP_FVBNJ_G0035008
 protein coding gene Chr9:103362091-103396711 (-)
LP/J MGP_LPJ_G0035136
 protein coding gene Chr9:109317605-109354391 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035047
 protein coding gene Chr9:117670269-117708930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035762
 protein coding gene Chr9:108036781-108073004 (-)
PWK/PhJ MGP_PWKPhJ_G0033949
 protein coding gene Chr9:104914551-104951113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033784
 protein coding gene Chr9:108097937-108138889 (-)
WSB/EiJ MGP_WSBEiJ_G0034363
 protein coding gene Chr9:107923384-107960696 (-)



Homology
more
  • Human Ortholog
    MAPKAPK3, MAPK activated protein kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPKAPK3, MAPK activated protein kinase 3
  • Synonyms
    3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MDPT3, MK-3, MK3
  • Links
    NCBI Gene ID: 7867
    neXtProt AC: NX_Q16644
    UniProt: Q16644

  • Chr Location
    3p21.2; chr3:50611520-50649291 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAPKAPK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines. Eyes of homozygous null mice show defects in Bruch's membrane, with disorganized architecture and variability in thickness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    37
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032577 Ensembl Gene Model | MGI Sequence Detail 34951 C57BL/6J ±  kb
    transcript ENSMUST00000035194 Ensembl | MGI Sequence Detail 2816 Not Applicable  
    polypeptide ENSMUSP00000035194 Ensembl | MGI Sequence Detail 384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory