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Il20rb Gene Detail
Summary
  • Symbol
    Il20rb
  • Name
    interleukin 20 receptor beta
  • Synonyms
    Fndc6, Il20R2, LOC213208
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143266
    NCBI Gene: 213208
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:100339772-100368526 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 52.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    920 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143266
 protein coding gene Chr9:100339772-100368841 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035176
 protein coding gene Chr9:101893489-101927838 (-)
A/J MGP_AJ_G0035157
 protein coding gene Chr9:98297834-98327734 (-)
AKR/J MGP_AKRJ_G0035089
 protein coding gene Chr9:100698713-100730446 (-)
BALB/cJ MGP_BALBcJ_G0035150
 protein coding gene Chr9:97980059-98009197 (-)
C3H/HeJ MGP_C3HHeJ_G0034860
 protein coding gene Chr9:101117919-101149897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035670
 protein coding gene Chr9:104815873-104844575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032569
 protein coding gene Chr9:95946433-95974371 (-)
CAST/EiJ MGP_CASTEiJ_G0034171
 protein coding gene Chr9:100900723-100932281 (-)
CBA/J MGP_CBAJ_G0034828
 protein coding gene Chr9:108435791-108469785 (-)
DBA/2J MGP_DBA2J_G0034990
 protein coding gene Chr9:97781499-97810569 (-)
FVB/NJ MGP_FVBNJ_G0034938
 protein coding gene Chr9:96594791-96623765 (-)
LP/J MGP_LPJ_G0035066
 protein coding gene Chr9:102122574-102155760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034977
 protein coding gene Chr9:110315948-110346925 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035692
 protein coding gene Chr9:100950073-100980009 (-)
PWK/PhJ MGP_PWKPhJ_G0033878
 protein coding gene Chr9:98005988-98035208 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033714
 protein coding gene Chr9:101004454-101032950 (-)
WSB/EiJ MGP_WSBEiJ_G0034291
 protein coding gene Chr9:100811217-100843753 (-)



Homology
more
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
  • Synonyms
    DIRS1, FNDC6, IL-20R2
  • Links
    NCBI Gene ID: 53833
    neXtProt AC: NX_Q6UXL0
    UniProt: Q6UXL0

  • Chr Location
    3q22.3; chr3:136946230-137011085 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 6 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    10
  • cDNA Data
    32
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213208 NCBI Gene Model | MGI Sequence Detail 28755 C57BL/6J ±  kb
    transcript NM_001033543 RefSeq | MGI Sequence Detail 2479 C57BL/6  
    polypeptide NP_001028715 RefSeq | MGI Sequence Detail 308 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR015373 Interferon/interleukin receptor domain
      IPR050650 Type II Cytokine and Tissue Factor Receptors
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 32

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2685032
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 23
    • Earliest
      J:124591 Chan JR, et al., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006 Nov 27;203(12):2577-87
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory