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Mief2 Gene Detail
Summary
  • Symbol
    Mief2
  • Name
    mitochondrial elongation factor 2
  • Synonyms
    LOC237781, Smcr7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144199
    NCBI Gene: 237781
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60619224-60623777 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144199
 protein coding gene Chr11:60619224-60623777 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018423
 protein coding gene Chr11:60642874-60647427 (+)
A/J MGP_AJ_G0018392
 protein coding gene Chr11:58411387-58415948 (+)
AKR/J MGP_AKRJ_G0018362
 protein coding gene Chr11:60264961-60269514 (+)
BALB/cJ MGP_BALBcJ_G0018363
 protein coding gene Chr11:58708359-58712912 (+)
C3H/HeJ MGP_C3HHeJ_G0018176
 protein coding gene Chr11:60199383-60203944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018815
 protein coding gene Chr11:62563877-62568430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016461
 protein coding gene Chr11:55554663-55559787 (+)
CAST/EiJ MGP_CASTEiJ_G0017733
 protein coding gene Chr11:60296800-60301361 (+)
CBA/J MGP_CBAJ_G0018150
 protein coding gene Chr11:65287102-65291663 (+)
DBA/2J MGP_DBA2J_G0018259
 protein coding gene Chr11:57997914-58002467 (+)
FVB/NJ MGP_FVBNJ_G0018250
 protein coding gene Chr11:57660131-57664666 (+)
LP/J MGP_LPJ_G0018332
 protein coding gene Chr11:61222310-61226863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018274
 protein coding gene Chr11:66342698-66347251 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018856
 protein coding gene Chr11:60355507-60360068 (+)
PWK/PhJ MGP_PWKPhJ_G0017506
 protein coding gene Chr11:58575431-58580029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017296
 protein coding gene Chr11:60174129-60178705 (+)
WSB/EiJ MGP_WSBEiJ_G0017785
 protein coding gene Chr11:59977519-59982074 (+)



Homology
more
  • Human Ortholog
    MIEF2, mitochondrial elongation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIEF2, mitochondrial elongation factor 2
  • Synonyms
    COXPD49, D3B, MID49, SMCR7
  • Links
    NCBI Gene ID: 125170
    neXtProt AC: NX_Q96C03
    UniProt: Q96C03

  • Chr Location
    17p11.2; chr17:18260597-18266552 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MIEF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 237781 NCBI Gene Model | MGI Sequence Detail 4554 C57BL/6J ±  kb
transcript NM_001009927 RefSeq | MGI Sequence Detail 2564 C57BL/6  
polypeptide Q5NCS9 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015278 Smith-Magenis syndrome chromosome region candidate gene 7 protein
    (term hierarchy)
  • PDB
    4WOY
  • InterPro Domains
    IPR024810 MAB21L/Cyclic GMP-AMP synthase-like receptor
    IPR046906 Mab-21-like, HhH/H2TH-like domain
    IPR045909 Mitochondrial dynamics protein MID49/MID51
    IPR049097 Mitochondrial dynamics protein MID51-like, C-terminal domain
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
less
MGI:2684857
References
more
  • Summaries
    All 44
    Diseases 2
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory