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Ptpdc1 Gene Detail
Summary
  • Symbol
    Ptpdc1
  • Name
    protein tyrosine phosphatase domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145430
    NCBI Gene: 218232
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:48731348-48779140 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 24.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1078 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145430
 protein coding gene Chr13:48731345-48779148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020525
 protein coding gene Chr13:47482713-47536321 (-)
A/J MGP_AJ_G0020479
 protein coding gene Chr13:45821382-45869074 (-)
AKR/J MGP_AKRJ_G0020456
 protein coding gene Chr13:47106148-47153827 (-)
BALB/cJ MGP_BALBcJ_G0020475
 protein coding gene Chr13:46034216-46082047 (-)
C3H/HeJ MGP_C3HHeJ_G0020274
 protein coding gene Chr13:46935307-46983030 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020908
 protein coding gene Chr13:48918704-48966396 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018493
 protein coding gene Chr13:43818474-43865012 (-)
CAST/EiJ MGP_CASTEiJ_G0019789
 protein coding gene Chr13:46923506-46971129 (-)
CBA/J MGP_CBAJ_G0020235
 protein coding gene Chr13:50950042-50997732 (-)
DBA/2J MGP_DBA2J_G0020357
 protein coding gene Chr13:45349185-45396869 (-)
FVB/NJ MGP_FVBNJ_G0020336
 protein coding gene Chr13:44860666-44908465 (-)
LP/J MGP_LPJ_G0020432
 protein coding gene Chr13:47730376-47768838 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020365
 protein coding gene Chr13:50714768-50762455 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020951
 protein coding gene Chr13:46787207-46839049 (-)
PWK/PhJ MGP_PWKPhJ_G0019545
 protein coding gene Chr13:45506834-45556982 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019373
 protein coding gene Chr13:45505082-45557468 (-)
WSB/EiJ MGP_WSBEiJ_G0019851
 protein coding gene Chr13:47117277-47164675 (-)



Homology
more
  • Human Ortholog
    PTPDC1, protein tyrosine phosphatase domain containing 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPDC1, protein tyrosine phosphatase domain containing 1
  • Synonyms
    PTP9Q22
  • Links
    NCBI Gene ID: 138639
    neXtProt AC: NX_A2A3K4
    UniProt: A2A3K4

  • Chr Location
    9q22.32; chr9:94030794-94109856 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice are viable, fertile and do not exhibit growth defects. A high throughput screen detected small testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    23
  • cDNA Data
    39
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038042 Ensembl Gene Model | MGI Sequence Detail 47793 C57BL/6J ±  kb
    transcript ENSMUST00000222028 Ensembl | MGI Sequence Detail 3164 Not Applicable  
    polypeptide ENSMUSP00000152771 Ensembl | MGI Sequence Detail 808 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031273 protein tyrosine phosphatase domain-containing protein 1
      (term hierarchy)
    • EC
      3.1.3.-
    • InterPro Domains
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR050561 Protein Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR049573 Protein tyrosine phosphatase domain-containing protein 1, PTP domain
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2145296
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory