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Nlrp4f Gene Detail
Summary
  • Symbol
    Nlrp4f
  • Name
    NLR family, pyrin domain containing 4F
  • Synonyms
    C330026N02Rik, Nalp4f, NALP9F, Nalp-kappa
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145528
    NCBI Gene: 97895
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:65324925-65353530 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 34.45 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    698 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145528
 protein coding gene Chr13:65324925-65353791 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020688
 protein coding gene Chr13:65204196-65227516 (-)
A/J MGP_AJ_G0020642
 protein coding gene Chr13:62823060-62845279 (-)
AKR/J MGP_AKRJ_G0020619
 protein coding gene Chr13:64904999-64927242 (-)
BALB/cJ MGP_BALBcJ_G0020640
 protein coding gene Chr13:63254753-63279042 (-)
C3H/HeJ MGP_C3HHeJ_G0020435
 protein coding gene Chr13:64437731-64460459 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021076
 protein coding gene Chr13:67325137-67354757 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018652
 protein coding gene Chr13:60511335-60538742 (-)
CAST/EiJ MGP_CASTEiJ_G0019952
 protein coding gene Chr13:64473942-64497166 (-)
CBA/J MGP_CBAJ_G0020395
 protein coding gene Chr13:69891376-69913644 (-)
DBA/2J MGP_DBA2J_G0020520
 protein coding gene Chr13:62666321-62688540 (-)
FVB/NJ MGP_FVBNJ_G0020499
 protein coding gene Chr13:61742596-61764815 (-)
LP/J MGP_LPJ_G0020594
 protein coding gene Chr13:65474754-65496972 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020528
 protein coding gene Chr13:68833298-68864066 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021118
 protein coding gene Chr13:64219343-64241605 (-)
PWK/PhJ MGP_PWKPhJ_G0019706
 protein coding gene Chr13:62236326-62259456 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0020012
 protein coding gene Chr13:64701245-64724851 (-)



Homology
more
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Synonyms
    CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
  • Links
    NCBI Gene ID: 147945
    neXtProt AC: NX_Q96MN2
    UniProt: Q96MN2

  • Chr Location
    19q13.43; chr19:55836540-55881855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility, a maternal effect on preimplantation embryo development, altered organelle distribution in zygotes and oocytes, and abnormal formation of microtubules and cytoplasmic lattices in oocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    37
  • cDNA Data
    75
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 97895 NCBI Gene Model | MGI Sequence Detail 28606 C57BL/6J ±  kb
    transcript NM_175290 RefSeq | MGI Sequence Detail 3527 C57BL/6  
    polypeptide Q66X05 UniProt | EBI | MGI Sequence Detail 959 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000011567 NACHT, LRR and PYD domains-containing protein 4F
      (term hierarchy)
    • InterPro Domains
      IPR004020 DAPIN domain
      IPR011029 Death-like domain superfamily
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR050637 NLRP family, innate immunity and inflammation regulators
      IPR041075 NOD2, winged helix domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 75
      Primer pair 5

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory