Ano6 MGI Mouse Gene Detail - MGI:2145890

Symbol

Ano6
Name

anoctamin 6
Synonyms

2900059G15Rik, F730003B03Rik, Tmem16f

Feature Type

protein coding gene
IDs

MGI:2145890
NCBI Gene: 105722
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr15:95688724-95872632 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 50.66 cM
Mapping Data

2 experiments

SNPs within 2kb

6492 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145890	protein coding gene	Chr15:95688724-95873353 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022266	protein coding gene	Chr15:97318275-97525840 (+)
A/J	MGP_AJ_G0022225	protein coding gene	Chr15:93526709-93714785 (+)
AKR/J	MGP_AKRJ_G0022200	protein coding gene	Chr15:96333050-96525708 (+)
BALB/cJ	MGP_BALBcJ_G0022231	protein coding gene	Chr15:93729965-93915459 (+)
C3H/HeJ	MGP_C3HHeJ_G0022001	protein coding gene	Chr15:96382843-96572521 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022676	protein coding gene	Chr15:100936749-101136854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020202	protein coding gene	Chr15:89525412-89711621 (+)
CAST/EiJ	MGP_CASTEiJ_G0021523	protein coding gene	Chr15:97228843-97422293 (+)
CBA/J	MGP_CBAJ_G0021968	protein coding gene	Chr15:104300645-104514537 (+)
DBA/2J	MGP_DBA2J_G0022095	protein coding gene	Chr15:92973301-93159454 (+)
FVB/NJ	MGP_FVBNJ_G0022074	protein coding gene	Chr15:91959030-92148452 (+)
LP/J	MGP_LPJ_G0022166	protein coding gene	Chr15:97448891-97645186 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022094	protein coding gene	Chr15:108556302-108753823 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022691	protein coding gene	Chr15:96448029-96651997 (+)
PWK/PhJ	MGP_PWKPhJ_G0021264	protein coding gene	Chr15:93038556-93232697 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021098	protein coding gene	Chr15:96233409-96434693 (+)
WSB/EiJ	MGP_WSBEiJ_G0021572	protein coding gene	Chr15:96952966-97159325 (+)

Human Ortholog

ANO6, anoctamin 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANO6, anoctamin 6
Synonyms

BDPLT7, SCTS, TMEM16F
Links

HGNC:25240

NCBI Gene ID: 196527

neXtProt AC: NX_Q4KMQ2

UniProt: Q4KMQ2
Chr Location

12q12; chr12:45215987-45482280 (+) GRCh38

MGI Vertebrate Homology

Ano6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANO6
Gene Tree

Ano6

Diseases

3 with human ANO6 associations

				Human Disease	Mouse Models
				ankylosing spondylitis IDs ankylosing spondylitis DOID:7147 EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 OMIM:PS106300 ORDO:825 UMLS_CUI:C0038013
				inflammatory bowel disease IDs inflammatory bowel disease DOID:0050589 EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 UMLS_CUI:C0021390
				Scott syndrome IDs Scott syndrome DOID:0111052 MESH:C563120 OMIM:262890 ORDO:806 UMLS_CUI:C0796149

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 4 alleles in 5 genetic backgrounds
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

10
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Ano6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired platelet coagulation with increased bleeding time. Mice homozygous for a different knock out allele or gene trap exhibit decreased bone mineral deposition and skeletal abnormalities.

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All GO Annotations

74
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

139
cDNA Data

179
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANO6

Xenbase ano6

ZFIN ano6

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All Sequences

65
RefSeq

12
UniProt

4
CCDS

CCDS37184.1, CCDS88829.1

Ensembl

ENSMUSG00000064210 (Evidence)
NCBI Gene

105722

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064210	Ensembl Gene Model \| MGI Sequence Detail	183909	C57BL/6J	± kb
transcript	ENSMUST00000227791	Ensembl \| MGI Sequence Detail	3149	Not Applicable
polypeptide	ENSMUSP00000153954	Ensembl \| MGI Sequence Detail	932	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004061 anoctamin-6

(term hierarchy)
PDB

6P46, 6P47, 6P48, 6P49, 6QP6, 6QPB, 6QPC, 6QPI, 8B8G, 8B8J, 8B8K, 8B8M, 8B8Q, 8BC0, 8BC1, 8SUN, 8SUR, 8TAG, 8TAI, 8TAL
InterPro Domains

IPR007632 Anoctamin

IPR032394 Anoctamin, dimerisation domain

IPR049452 Anoctamin, transmembrane domain
GlyGen

Q6P9J9 7 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 185

cDNA 180

Primer pair 5

Microarray probesets 4

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MGI:1920265, MGI:2146238

Summaries

All 92

Developmental Gene Expression 4

Diseases 1

Gene Ontology 16

Phenotypes 49
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:351620 Zubia MV, et al., TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2311831121

TSS for Ano6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132792	Chr15:95688712-95688740 (+)	2 bp
Tssr132793	Chr15:95688741-95688755 (+)	24 bp
Tssr132794	Chr15:95688765-95688781 (+)	49 bp
Tssr132795	Chr15:95688784-95688795 (+)	66 bp
Tssr132796	Chr15:95688803-95688814 (+)	85 bp
Tssr132797	Chr15:95688832-95688846 (+)	115 bp
Tssr132798	Chr15:95688852-95688889 (+)	147 bp
Tssr132799	Chr15:95698539-95698547 (+)	9,819 bp
Tssr132800	Chr15:95698576-95698588 (+)	9,858 bp
Tssr132801	Chr15:95699338-95699365 (+)	10,628 bp
Tssr4704	Chr15:95700895-95700898 (+)	12,173 bp
Tssr132802	Chr15:95727972-95728005 (+)	39,265 bp
Tssr132803	Chr15:95728006-95728023 (+)	39,291 bp
Tssr132804	Chr15:95728298-95728311 (+)	39,581 bp
Tssr132805	Chr15:95734823-95734827 (+)	46,101 bp
Tssr132806	Chr15:95750059-95750062 (+)	61,337 bp
Tssr132807	Chr15:95761973-95761998 (+)	73,262 bp
Tssr132808	Chr15:95841439-95841442 (+)	152,717 bp
Tssr132809	Chr15:95857034-95857042 (+)	168,314 bp
Tssr132810	Chr15:95857064-95857074 (+)	168,345 bp
Tssr132811	Chr15:95863774-95863787 (+)	175,057 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24