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Cblb Gene Detail
Summary
  • Symbol
    Cblb
  • Name
    Casitas B-lineage lymphoma b
  • Synonyms
    Cbl-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146430
    NCBI Gene: 208650
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:51851593-52028410 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 32.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146430
 protein coding gene Chr16:51851588-52028411 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022877
 protein coding gene Chr16:50966071-51153081 (+)
A/J MGP_AJ_G0022844
 protein coding gene Chr16:48745918-48927412 (+)
AKR/J MGP_AKRJ_G0022816
 protein coding gene Chr16:50381919-50563714 (+)
BALB/cJ MGP_BALBcJ_G0022844
 protein coding gene Chr16:48846542-49025822 (+)
C3H/HeJ MGP_C3HHeJ_G0022607
 protein coding gene Chr16:50462695-50649599 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023292
 protein coding gene Chr16:52330774-52518423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020804
 protein coding gene Chr16:48704423-48878356 (+)
CAST/EiJ MGP_CASTEiJ_G0022133
 protein coding gene Chr16:50824971-51018981 (+)
CBA/J MGP_CBAJ_G0022580
 protein coding gene Chr16:54392968-54603906 (+)
DBA/2J MGP_DBA2J_G0022712
 protein coding gene Chr16:48496854-48676365 (+)
FVB/NJ MGP_FVBNJ_G0022687
 protein coding gene Chr16:48332232-48509518 (+)
LP/J MGP_LPJ_G0022779
 protein coding gene Chr16:50771101-50955092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022705
 protein coding gene Chr16:54194025-54392800 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023307
 protein coding gene Chr16:50459497-50644128 (+)
PWK/PhJ MGP_PWKPhJ_G0021873
 protein coding gene Chr16:48822570-49000679 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021703
 protein coding gene Chr16:50263489-50450725 (+)
WSB/EiJ MGP_WSBEiJ_G0022178
 protein coding gene Chr16:50427195-50613105 (+)



Homology
more
  • Human Ortholog
    CBLB, Cbl proto-oncogene B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLB, Cbl proto-oncogene B
  • Synonyms
    ADMIO3, Cbl-b, Nbla00127, RNF56
  • Links
    NCBI Gene ID: 868
    neXtProt AC: NX_Q13191
    UniProt: Q13191

  • Chr Location
    3q13.11; chr3:105655461-105869552 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CBLB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit elevated IL2 production by T cells, develop spontaneous autoimmunity, and are highly susceptible to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    10
  • cDNA Data
    45
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 208650 NCBI Gene Model | MGI Sequence Detail 176818 C57BL/6J ±  kb
transcript NM_001033238 RefSeq | MGI Sequence Detail 6323 C57BL/6  
polypeptide Q3TTA7 UniProt | EBI | MGI Sequence Detail 982 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146506
References
more
  • Summaries
    All 147
    Developmental Gene Expression 2
    Gene Ontology 17
    Phenotypes 94
  • Earliest
    J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
  • Latest
    J:354878 Li X, et al., Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. Immunity. 2024 May 12;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory