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Catsperd Gene Detail
Summary
  • Symbol
    Catsperd
  • Name
    cation channel sperm associated auxiliary subunit delta
  • Synonyms
    4921529N20Rik, 4933402B14Rik, Gm6095, Tmem146
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147030
    NCBI Gene: 106757
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56935143-56971456 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    984 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147030
 protein coding gene Chr17:56933917-56971456 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023933
 protein coding gene Chr17:58331123-58373901 (+)
A/J MGP_AJ_G0023891
 protein coding gene Chr17:56740544-56776762 (+)
AKR/J MGP_AKRJ_G0023860
 protein coding gene Chr17:57439141-57479707 (+)
BALB/cJ MGP_BALBcJ_G0023892
 protein coding gene Chr17:56557773-56595606 (+)
C3H/HeJ MGP_C3HHeJ_G0023656
 protein coding gene Chr17:58172418-58213900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024338
 protein coding gene Chr17:60589517-60634589 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021784
 protein coding gene Chr17:53214417-53252863 (+)
CAST/EiJ MGP_CASTEiJ_G0023138
 protein coding gene Chr17:58451845-58490282 (+)
CBA/J MGP_CBAJ_G0023632
 protein coding gene Chr17:62964305-63005866 (+)
DBA/2J MGP_DBA2J_G0023760
 protein coding gene Chr17:55441627-55477663 (+)
FVB/NJ MGP_FVBNJ_G0023726
 protein coding gene Chr17:54980874-55025345 (+)
LP/J MGP_LPJ_G0023842
 protein coding gene Chr17:59019543-59061165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023754
 protein coding gene Chr17:62455491-62493981 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024382
 protein coding gene Chr17:57805750-57845637 (+)
PWK/PhJ MGP_PWKPhJ_G0022884
 protein coding gene Chr17:54801189-54837544 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022695
 protein coding gene Chr17:54569019-54612478 (+)
WSB/EiJ MGP_WSBEiJ_G0023204
 protein coding gene Chr17:58414819-58457942 (+)



Homology
more
  • Human Ortholog
    CATSPERD, cation channel sperm associated auxiliary subunit delta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CATSPERD, cation channel sperm associated auxiliary subunit delta
  • Synonyms
    TMEM146
  • Links
    NCBI Gene ID: 257062
    neXtProt AC: NX_Q86XM0
    UniProt: Q86XM0

  • Chr Location
    19p13.3; chr19:5720637-5778734 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion in this gene display male infertility. Hyperactivity of sperm fails to develop under capacitating conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040828 Ensembl Gene Model | MGI Sequence Detail 36314 C57BL/6J ±  kb
    transcript ENSMUST00000112979 Ensembl | MGI Sequence Detail 2557 Not Applicable  
    polypeptide ENSMUSP00000108603 Ensembl | MGI Sequence Detail 805 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031295 cation channel sperm-associated auxiliary subunit delta
      (term hierarchy)
    • PDB
      7EEB
    • InterPro Domains
      IPR028751 Cation channel sperm-associated auxiliary subunit delta/epsilon
    • GlyGen
      E9Q9F6 5 sites
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918194, MGI:3779551
    References
    more
    • Summaries
      All 30
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326743 Zhao Y, et al., 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nat Commun. 2022 Jun 17;13(1):3439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory