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Cyp2c50 Gene Detail
Summary
  • Symbol
    Cyp2c50
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 50
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147497
    NCBI Gene: 107141
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40078132-40102394 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.24 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    924 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147497
 protein coding gene Chr19:40078123-40102399 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025108
 protein coding gene Chr19:39278446-39302726 (+)
A/J MGP_AJ_G0025085
 protein coding gene Chr19:37360306-37381901 (+)
AKR/J MGP_AKRJ_G0025053
 protein coding gene Chr19:38627417-38651849 (+)
BALB/cJ MGP_BALBcJ_G0025079
 protein coding gene Chr19:37444617-37468263 (+)
C3H/HeJ MGP_C3HHeJ_G0024839
 protein coding gene Chr19:38740864-38777501 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0022936
 protein coding gene Chr19:36808615-36833885 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024819
 protein coding gene Chr19:42311991-42337976 (+)
DBA/2J MGP_DBA2J_G0024951
 protein coding gene Chr19:37250717-37276581 (+)
FVB/NJ MGP_FVBNJ_G0024912
 protein coding gene Chr19:37019196-37039116 (+)
LP/J MGP_LPJ_G0025037
 protein coding gene Chr19:39302777-39327063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024943
 protein coding gene Chr19:42014632-42053631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025580
 protein coding gene Chr19:38664982-38698303 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0023857
 protein coding gene Chr19:37412967-37451554 (+)
WSB/EiJ MGP_WSBEiJ_G0024374
 protein coding gene Chr19:38806894-38828071 (+)



Homology
more
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Synonyms
    CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
  • Links
    NCBI Gene ID: 1562
    neXtProt AC: NX_P33260
    UniProt: P33260

  • Chr Location
    10q23.33; chr10:94683729-94736190 (+)  GRCh38
  • Human Ortholog
    CYP2C19, cytochrome P450 family 2 subfamily C member 19
  • Synonyms
    CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
  • Links
    NCBI Gene ID: 1557
    neXtProt AC: NX_P33261
    UniProt: P33261

  • Chr Location
    10q23.33; chr10:94762681-94855547 (+)  GRCh38
  • Human Ortholog
    CYP2C8, cytochrome P450 family 2 subfamily C member 8
  • Synonyms
    CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
  • Links
    NCBI Gene ID: 1558
    neXtProt AC: NX_P10632
    UniProt: P10632

  • Chr Location
    10q23.33; chr10:95036772-95069497 (-)  GRCh38
  • Human Ortholog
    CYP2C9, cytochrome P450 family 2 subfamily C member 9
  • Synonyms
    CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
  • Links
    NCBI Gene ID: 1559
    neXtProt AC: NX_P11712
    UniProt: P11712

  • Chr Location
    10q23.33; chr10:94938658-94990091 (+)  GRCh38
Human Diseases
more
  • Diseases
    21 with human CYP2C19,CYP2C8,CYP2C9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    49
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054827 Ensembl Gene Model | MGI Sequence Detail 24263 C57BL/6J ±  kb
transcript ENSMUST00000080171 Ensembl | MGI Sequence Detail 1812 Not Applicable  
polypeptide ENSMUSP00000079065 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:113341 Wang H, et al., Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Mol Pharmacol. 2004 May;65(5):1148-58
  • Latest
    J:358008 Zhang D, et al., Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Mol Metab. 2024 May 11;85:101957
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory